Gab 1 Antibody (G-9): sc-271848

Gab 1 Antibody (G-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects Gab 1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Gab 1 antibody (G-9) plays a crucial role in cellular signaling pathways, particularly in the context of growth factor receptor activation. Gab 1, known as GRB-associated binder-1, functions as an essential adapter protein that facilitates the transmission of signals from activated receptor tyrosine kinases to downstream signaling molecules. Gab 1′s ability to interact with other key proteins, such as GRB2 and Sos, is vital for linking the insulin receptor to the Ras signaling pathway, which is critical for various cellular responses, including cell growth and differentiation. Additionally, Gab 1 is implicated in the epidermal growth factor receptor signaling pathway, highlighting Gab 1′s importance in mediating responses to growth factors. Proper functioning of Gab 1 is essential for maintaining normal cellular processes, and dysregulation of Gab 1 signaling pathways can lead to various diseases, including cancer. With specificity for Gab 1 and versatility in multiple applications, Gab 1 monoclonal antibody (G-9) serves as an invaluable tool for researchers studying the intricate mechanisms of cell signaling and the role of adapter proteins in health and disease.

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Gab 1 Antibody (G-9) References:

1. Gab-1-mediated IGF-1 signaling in IRS-1-deficient 3T3 fibroblasts.  |  Winnay, JN., et al. 2000. J Biol Chem. 275: 10545-50. PMID: 10744748
2. The osmotic shock-induced glucose transport pathway in 3T3-L1 adipocytes is mediated by gab-1 and requires Gab-1-associated phosphatidylinositol 3-kinase activity for full activation.  |  Janez, A., et al. 2000. J Biol Chem. 275: 26870-6. PMID: 10842168
3. The versatile role of Gab1 in the circulatory system.  |  Wöhrle, FU., et al. 2012. Circ J. 76: 1838-9. PMID: 22785000
4. Gab1 regulates SDF-1-induced progression via inhibition of apoptosis pathway induced by PI3K/AKT/Bcl-2/BAX pathway in human chondrosarcoma.  |  Fan, Y., et al. 2016. Tumour Biol. 37: 1141-9. PMID: 26276357
5. Recurrent Fusion of the GRB2 Associated Binding Protein 1 (GAB1) Gene With ABL Proto-oncogene 1 (ABL1) in Benign Pediatric Soft Tissue Tumors.  |  Panagopoulos, I., et al. 2020. Cancer Genomics Proteomics. 17: 499-508. PMID: 32859628
6. Gab1 in livers with persistent hepatocyte apoptosis has an antiapoptotic effect and reduces chronic liver injury, fibrosis, and tumorigenesis.  |  Mizutani, N., et al. 2021. Am J Physiol Gastrointest Liver Physiol. 320: G958-G968. PMID: 33787344
7. GAB1 is upregulated to promote anaplastic thyroid cancer cell migration through AKT-MDR1.  |  Song, P., et al. 2022. Biochem Biophys Res Commun. 607: 36-43. PMID: 35366541
8. Gab1 regulates invadopodia and autocrine VEGF through SHP2/ERK1/2 in hilar cholangiocarcinoma cells.  |  Li, T., et al. 2022. Am J Transl Res. 14: 8934-8946. PMID: 36628230
9. GAB1 as a Marker of Recurrence in Anterior Skull Base Meningioma.  |  Boetto, J., et al. 2023. Neurosurgery. 92: 391-397. PMID: 36637273
10. GAB1 attenuates lipopolysaccharide‑mediated endothelial dysfunction via regulation of SOCS3.  |  Ren, G., et al. 2024. Exp Ther Med. 28: 400. PMID: 39171145

The preferred Gab 1 antibody is Gab 1 Antibody (H-7): sc-133191.