Fyb Antibody (H-3): sc-393276
- Fyb Antibody (H-3) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 504-614 mapping within an internal region of Fyb of human origin
- recommended for detection of Fyb of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Fyb Antibody (H-3) for WB applications. These reagents are now offered in bundles with Fyb Antibody (H-3) (see ordering information below).
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Fyb Antibody (H-3) is a mouse monoclonal IgG1 antibody that detects Fyb in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Fyb, also known as Fyn binding protein, plays a crucial role in T cell signaling by interacting with the tyrosine kinase p59fyn and anchoring proteins like SKAP55 and SKAP55-R. Anti-Fyb antibody (H-3) enables research into Fyb′s ability to facilitate the assembly of signaling complexes essential for T cell activation, which is vital for the adaptive immune response. Specifically, Fyb′s interaction with SKAP55 and SKAP55-R, both of which contain SH3 domains, allows for the regulation of signaling events initiated by lymphocyte antigen receptors. The human Fyb gene, located on chromosome 5p13.1, encodes a 783 amino acid protein that is integral to the proper functioning of immune responses. Fyb monoclonal antibody (H-3) serves as an invaluable tool for researchers studying T cell activation and the underlying mechanisms of immune signaling.
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Fyb Antibody (H-3) References:
- Novel isoform of lymphoid adaptor FYN-T-binding protein (FYB-130) interacts with SLP-76 and up-regulates interleukin 2 production. | Veale, M., et al. 1999. J Biol Chem. 274: 28427-35. PMID: 10497204
- Cutting edge: SLP-76 cooperativity with FYB/FYN-T in the Up-regulation of TCR-driven IL-2 transcription requires SLP-76 binding to FYB at Tyr595 and Tyr651. | Geng, L., et al. 1999. J Immunol. 163: 5753-7. PMID: 10570256
- Cutting edge: a novel function for the SLAP-130/FYB adapter protein in beta 1 integrin signaling and T lymphocyte migration. | Hunter, AJ., et al. 2000. J Immunol. 164: 1143-7. PMID: 10640723
- Adaptor FYB (Fyn-binding protein) regulates integrin-mediated adhesion and mediator release: differential involvement of the FYB SH3 domain. | Geng, L., et al. 2001. Proc Natl Acad Sci U S A. 98: 11527-32. PMID: 11553777
- Coupling of the TCR to integrin activation by Slap-130/Fyb. | Peterson, EJ., et al. 2001. Science. 293: 2263-5. PMID: 11567141
- Discovery of the expected haemagglutinin, anti-Fyb. | IKIN, EW., et al. 1951. Nature. 168: 1077-8. PMID: 14910641
- Interaction between the Yersinia tyrosine phosphatase YopH and its macrophage substrate, Fyn-binding protein, Fyb. | Yuan, M., et al. 2005. J Mol Microbiol Biotechnol. 9: 214-23. PMID: 16415594
- Molecular basis of inherited thrombocytopenias: an update. | Savoia, A. 2016. Curr Opin Hematol. 23: 486-92. PMID: 27438527
- ADAP restraint of STAT1 signaling regulates macrophage phagocytosis in immune thrombocytopenia. | Xiong, Y., et al. 2022. Cell Mol Immunol. 19: 898-912. PMID: 35637282
- Red-cell auto-antibodies mimicking anti-Fyb specificity. | van 't Veer, MB., et al. 1984. Vox Sang. 47: 88-91. PMID: 6741036
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fyb Antibody (H-3) | sc-393276 | 200 µg/ml | $322.00 | |||
Fyb Antibody (H-3): m-IgG Fc BP-HRP Bundle | sc-540895 | 200 µg Ab; 10 µg BP | $361.00 | |||
Fyb Antibody (H-3): m-IgG1 BP-HRP Bundle | sc-542447 | 200 µg Ab; 20 µg BP | $361.00 |