Furin Antibody (G-6): sc-133141
- Furin Antibody (G-6) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 575-794 of Furin of human origin
- Anti-Furin Antibody (G-6) is recommended for detection of Furin of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-Furin Antibody (G-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Furin Antibody (G-6) for WB and IHC(P) applications. These reagents are now offered in bundles with Furin Antibody (G-6) (see ordering information below).
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Furin Antibody (G-6) is a mouse monoclonal IgG2a kappa light chain antibody that detects Furin in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Furin (G-6) antibody is available in both non-conjugated and multiple conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates. Furin, also known as FUR, PACE, PCSK3, SPC1, and Kex2p, is a calcium-dependent serine endoprotease that plays a crucial role in processing latent precursor proteins into active forms, essential for numerous physiological processes. Located primarily in the trans-Golgi network, Furin′s activity requires tight regulation to prevent premature activation that could lead to unwanted protein degradation or activation. Furin is synthesized as an inactive zymogen, with an inactivating prosegment at its N-terminal that maintains inactivity until reaching the trans-Golgi network. Upon autocatalytic cleavage, the prosegment dissociates, allowing Furin to cleave various substrates, including proparathyroid hormone and transforming growth factor beta 1 precursor, thereby influencing critical biological pathways such as cell signaling and tissue remodeling. Furin specifically cleaves proMMP-2 within the trans-Golgi network, highlighting its importance in regulating matrix metalloproteinase activity, which is vital for extracellular matrix turnover and cellular communication.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Furin Antibody (G-6) References:
- The proprotein convertase furin in tumour progression. | Jaaks, P. and Bernasconi, M. 2017. Int J Cancer. 141: 654-663. PMID: 28369813
- Furin-mediated protein processing in infectious diseases and cancer. | Braun, E. and Sauter, D. 2019. Clin Transl Immunology. 8: e1073. PMID: 31406574
- The proprotein convertase furin in cancer: more than an oncogene. | He, Z., et al. 2022. Oncogene. 41: 1252-1262. PMID: 34997216
- Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity. | Essalmani, R., et al. 2022. J Virol. 96: e0012822. PMID: 35343766
- The emerging role of furin in neurodegenerative and neuropsychiatric diseases. | Zhang, Y., et al. 2022. Transl Neurodegener. 11: 39. PMID: 35996194
- 1,25-Dihydroxyvitamin D3 regulates furin-mediated FGF23 cleavage. | Xie, H., et al. 2023. JCI Insight. 8: PMID: 37681408
- An Overview of the Role of Furin in Type 2 Diabetes. | Marafie, SK. and Al-Mulla, F. 2023. Cells. 12: PMID: 37830621
- Cerebral furin deficiency causes hydrocephalus in mice. | Xie, S., et al. 2024. Genes Dis. 11: 101009. PMID: 38292192
- Functional Roles of Furin in Cardio-Cerebrovascular Diseases. | Wichaiyo, S., et al. 2024. ACS Pharmacol Transl Sci. 7: 570-585. PMID: 38481703
- The proprotein convertase FURIN is a novel aneurysm predisposition gene impairing TGF-β signalling. | He, Z., et al. 2024. Cardiovasc Res. 120: 2278-2292. PMID: 38636100
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Furin Antibody (G-6) | sc-133141 | 200 µg/ml | $316.00 | |||
Furin Antibody (G-6): m-IgG Fc BP-HRP Bundle | sc-528752 | 200 µg Ab; 10 µg BP | $354.00 | |||
Furin Antibody (G-6): m-IgGκ BP-HRP Bundle | sc-521249 | 200 µg Ab, 40 µg BP | $354.00 | |||
Furin Antibody (G-6): m-IgG2a BP-HRP Bundle | sc-547157 | 200 µg Ab; 10 µg BP | $354.00 | |||
Furin Antibody (G-6) AC | sc-133141 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Furin Antibody (G-6) HRP | sc-133141 HRP | 200 µg/ml | $316.00 | |||
Furin Antibody (G-6) FITC | sc-133141 FITC | 200 µg/ml | $330.00 | |||
Furin Antibody (G-6) PE | sc-133141 PE | 200 µg/ml | $343.00 | |||
Furin Antibody (G-6) Alexa Fluor® 488 | sc-133141 AF488 | 200 µg/ml | $357.00 | |||
Furin Antibody (G-6) Alexa Fluor® 546 | sc-133141 AF546 | 200 µg/ml | $357.00 | |||
Furin Antibody (G-6) Alexa Fluor® 594 | sc-133141 AF594 | 200 µg/ml | $357.00 | |||
Furin Antibody (G-6) Alexa Fluor® 647 | sc-133141 AF647 | 200 µg/ml | $357.00 | |||
Furin Antibody (G-6) Alexa Fluor® 680 | sc-133141 AF680 | 200 µg/ml | $357.00 | |||
Furin Antibody (G-6) Alexa Fluor® 790 | sc-133141 AF790 | 200 µg/ml | $357.00 |