FUCA2 Antibody (B-11): sc-514038
- FUCA2 Antibody (B-11) is a mouse monoclonal IgG2b κ FUCA2 antibody provided at 200 µg/ml
- raised against amino acids 307-338 mapping within an internal region of FUCA2 of human origin
- FUCA2 Antibody (B-11) is recommended for detection of FUCA2 of mouse, rat, human origin by WB, IP, IF and ELISA
- Anti-FUCA2 Antibody (B-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for FUCA2 Antibody (B-11) for WB applications. These reagents are now offered in bundles with FUCA2 Antibody (B-11) (see ordering information below).
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FUCA2 Antibody (B-11) is a mouse monoclonal IgG2b kappa light chain antibody that detects FUCA2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FUCA2 (B-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FUCA2 protein, also known as alpha-L-fucosidase 2, is a 467 amino acid secreted protein that forms a homotetramer and is specifically localized to plasma, distinguishing FUCA2 from FUCA1, which is found in tissues. As a member of the glycosyl hydrolase family, FUCA2 plays a crucial role in catalyzing the hydrolysis of alpha-L-fucosides, particularly targeting the alpha-1,6-linked fucose attached to N-acetylglucosamine residues in glycoproteins. This enzymatic activity is vital for maintaining the balance of alpha-L-fucosidase levels in plasma; any genetic defects leading to a loss of catalytic function can result in decreased enzyme levels and contribute to the development of fucosidosis, a rare autosomal recessive glycoprotein storage disorder characterized by symptoms such as organomegaly, cognitive impairment, and vascular abnormalities. Anti-FUCA2 antibody (B-11) effectively detects and quantifies FUCA2, making this antibody an essential tool for research into fucosidosis and related metabolic disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
FUCA2 Antibody (B-11) References:
- Characterization of human semen alpha-L-fucosidases. | Alhadeff, JA., et al. 1999. Mol Hum Reprod. 5: 809-15. PMID: 10460218
- Cell surface human alpha-L-fucosidase. | Cordero, OJ., et al. 2001. Eur J Biochem. 268: 3321-31. PMID: 11389735
- Purification and characterization of human seminal plasma alpha-L-fucosidase. | Khunsook, S., et al. 2002. Mol Hum Reprod. 8: 221-7. PMID: 11870229
- Biochemical and genetic studies of plasma and leukocyte alpha-L-fucosidase. | Ng, WG., et al. 1976. Am J Hum Genet. 28: 42-50. PMID: 1247019
- Stabilization of membrane-associated alpha-L-fucosidase by the human sperm equatorial segment. | Venditti, JJ. and Bean, BS. 2009. Int J Androl. 32: 556-62. PMID: 18522672
- Molecular biology of the alpha-L-fucosidase gene and fucosidosis. | O'Brien, JS., et al. 1987. Enzyme. 38: 45-53. PMID: 2894306
- An alpha-fucosidase pseudogene on human chromosome 2. | Carritt, B. and Welch, HM. 1987. Hum Genet. 75: 248-50. PMID: 3030924
- Linkage of plasma alpha-L-fucosidase (FUCA2) and the plasminogen (PLG) system. | Eiberg, H., et al. 1984. Clin Genet. 26: 23-9. PMID: 6590153
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FUCA2 Antibody (B-11) | sc-514038 | 200 µg/ml | $322.00 | |||
FUCA2 Antibody (B-11): m-IgG Fc BP-HRP Bundle | sc-531009 | 200 µg Ab; 10 µg BP | $361.00 | |||
FUCA2 Antibody (B-11): m-IgGκ BP-HRP Bundle | sc-524581 | 200 µg Ab, 40 µg BP | $361.00 | |||
FUCA2 Antibody (B-11): m-IgG2b BP-HRP Bundle | sc-550249 | 200 µg Ab; 10 µg BP | $361.00 | |||
FUCA2 Antibody (B-11) AC | sc-514038 AC | 500 µg/ml, 25% agarose | $424.00 | |||
FUCA2 Antibody (B-11) HRP | sc-514038 HRP | 200 µg/ml | $322.00 | |||
FUCA2 Antibody (B-11) FITC | sc-514038 FITC | 200 µg/ml | $336.00 | |||
FUCA2 Antibody (B-11) PE | sc-514038 PE | 200 µg/ml | $349.00 | |||
FUCA2 Antibody (B-11) Alexa Fluor® 488 | sc-514038 AF488 | 200 µg/ml | $364.00 | |||
FUCA2 Antibody (B-11) Alexa Fluor® 546 | sc-514038 AF546 | 200 µg/ml | $364.00 | |||
FUCA2 Antibody (B-11) Alexa Fluor® 594 | sc-514038 AF594 | 200 µg/ml | $364.00 | |||
FUCA2 Antibody (B-11) Alexa Fluor® 647 | sc-514038 AF647 | 200 µg/ml | $364.00 | |||
FUCA2 Antibody (B-11) Alexa Fluor® 680 | sc-514038 AF680 | 200 µg/ml | $364.00 | |||
FUCA2 Antibody (B-11) Alexa Fluor® 790 | sc-514038 AF790 | 200 µg/ml | $364.00 |