FTSJ1 Antibody (B-2): sc-390355

FTSJ1 Antibody (B-2) is a mouse monoclonal IgG2a kappa light chain antibody that detects FTSJ1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FTSJ1 (B-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FTSJ1 protein, also known as putative ribosomal RNA methyltransferase 1, plays a crucial role in the modification and processing of ribosomal RNA, which is essential for proper assembly and function of ribosomes. FTSJ1 protein is primarily located in the nucleolus, where FTSJ1 participates in the maturation of rRNA, a process vital for protein synthesis in all living cells. FTSJ1 is encoded by a gene located on human chromosome Xp11.23 and exists as multiple spliced isoforms, highlighting complex regulation and functional diversity. Mutations in FTSJ1 gene are associated with mental retardation X-linked type 44 (MRX44) and nonsyndromic X-linked mental retardation (MRX9), underscoring FTSJ1′s significance in neurodevelopmental processes.

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FTSJ1 Antibody (B-2) References:

1. Four families (MRX43, MRX44, MRX45, MRX52) with nonspecific X-linked mental retardation: clinical and psychometric data and results of linkage analysis.  |  Hamel, BC., et al. 1999. Am J Med Genet. 85: 290-304. PMID: 10398246
2. Spb1p is a yeast nucleolar protein associated with Nop1p and Nop58p that is able to bind S-adenosyl-L-methionine in vitro.  |  Pintard, L., et al. 2000. Mol Cell Biol. 20: 1370-81. PMID: 10648622
3. Nonsyndromic X-linked mental retardation: where are the missing mutations?  |  Ropers, HH., et al. 2003. Trends Genet. 19: 316-20. PMID: 12801724
4. Mutations in the FTSJ1 gene coding for a novel S-adenosylmethionine-binding protein cause nonsyndromic X-linked mental retardation.  |  Freude, K., et al. 2004. Am J Hum Genet. 75: 305-9. PMID: 15162322
5. A splice site mutation in the methyltransferase gene FTSJ1 in Xp11.23 is associated with non-syndromic mental retardation in a large Belgian family (MRX9).  |  Ramser, J., et al. 2004. J Med Genet. 41: 679-83. PMID: 15342698
6. FTSJ1 regulates tRNA 2'-O-methyladenosine modification and suppresses the malignancy of NSCLC via inhibiting DRAM1 expression.  |  He, Q., et al. 2020. Cell Death Dis. 11: 348. PMID: 32393790
7. Intellectual disability-associated gene ftsj1 is responsible for 2'-O-methylation of specific tRNAs.  |  Li, J., et al. 2020. EMBO Rep. 21: e50095. PMID: 32558197
8. Loss of Ftsj1 perturbs codon-specific translation efficiency in the brain and is associated with X-linked intellectual disability.  |  Nagayoshi, Y., et al. 2021. Sci Adv. 7: PMID: 33771871
9. Deficiency in FTSJ1 Affects Neuronal Plasticity in the Hippocampal Formation of Mice.  |  von Bohlen Und Halbach, V., et al. 2022. Biology (Basel). 11: PMID: 36101392
10. The ribose methylation enzyme FTSJ1 has a conserved role in neuron morphology and learning performance.  |  Brazane, M., et al. 2023. Life Sci Alliance. 6: PMID: 36720500
11. Investigating the Inhibition of FTSJ1, a Tryptophan tRNA-Specific 2'-O-Methyltransferase by NV TRIDs, as a Mechanism of Readthrough in Nonsense Mutated CFTR.  |  Carollo, PS., et al. 2023. Int J Mol Sci. 24: PMID: 37298560
12. Localization of a gene responsible for nonspecific mental retardation (MRX9) to the pericentromeric region of the X chromosome.  |  Willems, P., et al. 1993. Genomics. 18: 290-4. PMID: 8288232

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FTSJ1 Antibody (B-2) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-FTSJ1 Antibody (B-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FTSJ1 Antibody (B-2) Specifications

Alternate Product Name: FTSJ1

Product Clone Name: B-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 51-210

Epitope Target: FTSJ1

Epitope Species: human

Product Reactivity/Detection: FTSJ1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for FTSJ1 Antibody (B-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin