FTCD Antibody (C-1): sc-398522

FTCD Antibody (C-1) is a mouse monoclonal IgG1 antibody that detects FTCD in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FTCD, or formiminotransferase-cyclodeaminase, is a bifunctional enzyme crucial for the metabolism of histidine, as FTCD facilitates the transfer of 1-carbon units from formiminoglutamate to the folate pool, thereby playing a significant role in one-carbon metabolism. This process is vital for DNA synthesis and repair, as well as for the production of neurotransmitters, which are essential for proper brain function. Deficiencies in FTCD can lead to glutamate formiminotransferase deficiency, an autosomal recessive disorder characterized by severe symptoms such as elevated urinary levels of formiminoglutamate following histidine administration, megaloblastic anemia, and cognitive impairments. In milder cases, individuals may exhibit high urinary excretion of formiminoglutamate without histidine administration, along with mild developmental delays and no significant hematological issues. Anti-FTCD antibody (C-1) is an invaluable tool for researchers studying the Golgi complex and the metabolic pathways associated with histidine degradation, providing insights into the biochemical mechanisms underlying these disorders.

The preferred FTCD antibody is FTCD Antibody (G-3): sc-271788.