FTCD Antibody (G-3): sc-271788

FTCD Antibody (G-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects FTCD protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FTCD (G-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FTCD protein, also known as the 58K protein, plays a crucial role as a bifunctional enzyme that facilitates the transfer of 1-carbon units from formiminoglutamate, a key metabolite in the histidine degradation pathway, to the folate pool, which is essential for DNA synthesis and repair. This function is particularly important as FTCD links amino acid metabolism to folate metabolism, thereby influencing cellular proliferation and overall health. Defects in FTCD gene can lead to glutamate formiminotransferase deficiency, an autosomal recessive disorder characterized by elevated levels of formiminoglutamate in urine, megaloblastic anemia, and developmental challenges. The severity of the phenotype can vary, with some individuals exhibiting significant symptoms while others may only show mild developmental delays. FTCD (G-3) monoclonal antibody provides researchers with a valuable tool for studying the implications of FTCD in metabolic disorders and potential role in therapeutic interventions.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

FTCD Antibody (G-3) References:

1. A novel type of regulation of the vimentin intermediate filament cytoskeleton by a Golgi protein.  |  Gao, YS., et al. 2002. Eur J Cell Biol. 81: 391-401. PMID: 12160147
2. Characterization of the antigenicity of the formiminotransferase-cyclodeaminase in type 2 autoimmune hepatitis.  |  Renous, R., et al. 2004. Exp Cell Res. 292: 332-41. PMID: 14697341
3. Structure of the bifunctional and Golgi-associated formiminotransferase cyclodeaminase octamer.  |  Mao, Y., et al. 2004. EMBO J. 23: 2963-71. PMID: 15272307
4. Localization of Golgi 58K protein (formiminotransferase cyclodeaminase) to the centrosome.  |  Hagiwara, H., et al. 2006. Histochem Cell Biol. 126: 251-9. PMID: 16534631
5. A formiminotransferase cyclodeaminase isoform is localized to the Golgi complex and can mediate interaction of trans-Golgi network-derived vesicles with microtubules.  |  Hennig, D., et al. 1998. J Biol Chem. 273: 19602-11. PMID: 9677386
6. 58K, a microtubule-binding Golgi protein, is a formiminotransferase cyclodeaminase.  |  Bashour, AM. and Bloom, GS. 1998. J Biol Chem. 273: 19612-7. PMID: 9677387
7. Molecular cloning, characterization, and dynamics of rat formiminotransferase cyclodeaminase, a Golgi-associated 58-kDa protein.  |  Gao, YS., et al. 1998. J Biol Chem. 273: 33825-34. PMID: 9837973

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FTCD Antibody (G-3) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-FTCD Antibody (G-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FTCD Antibody (G-3) Specifications

Alternate Product Name: FTCD

Product Clone Name: G-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 33-67

Epitope Target: FTCD

Epitope Species: human

Product Reactivity/Detection: FTCD isoforms A, D, E and C

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for FTCD Antibody (G-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin