FRMD8 Antibody (E-11): sc-514186
- FRMD8 Antibody (E-11) is a mouse monoclonal IgG1 κ FRMD8 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 5-24 at the N-terminus of FRMD8 of human origin
- FRMD8 Antibody (E-11) is recommended for detection of FRMD8 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-FRMD8 Antibody (E-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for FRMD8 Antibody (E-11) for WB applications. These reagents are now offered in bundles with FRMD8 Antibody (E-11) (see ordering information below).
QUICK LINKS
FRMD8 Antibody (E-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects FRMD8 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FRMD8 (E-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FRMD8 protein, also known as FERM domain-containing protein 8 or FKSG44, is a 464 amino acid protein characterized by the presence of a single FERM domain, which is crucial for linking cytoskeletal signals to membrane dynamics. FRMD8 is involved in various cellular processes, including cell adhesion and migration, making FRMD8 significant in developmental biology and cancer research. The gene encoding FRMD8 is located on human chromosome 11q13.1, a region known for association with several genetic disorders, including Wilms′ tumors and WAGR syndrome, highlighting FRMD8′s importance in both normal physiology and disease states. Through interactions with other cytoskeletal-associated proteins, FRMD8 plays a vital role in maintaining cellular integrity and function, making anti-FRMD8 antibody (E-11) an essential tool for researchers studying these critical biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
FRMD8 Antibody (E-11) References:
- The 11q terminal deletion disorder: a prospective study of 110 cases. | Grossfeld, PD., et al. 2004. Am J Med Genet A. 129A: 51-61. PMID: 15266616
- Human chromosome 11 DNA sequence and analysis including novel gene identification. | Taylor, TD., et al. 2006. Nature. 440: 497-500. PMID: 16554811
- KCNQ1 K+ channel-mediated cardiac channelopathies. | Loussouarn, G., et al. 2006. Methods Mol Biol. 337: 167-83. PMID: 16929947
- Skipping of Exon 1 in the KCNQ1 gene causes Jervell and Lange-Nielsen syndrome. | Zehelein, J., et al. 2006. J Biol Chem. 281: 35397-403. PMID: 16987820
- Beta-thalassaemia and sickle cell anaemia as paradigms of hypercoagulability. | Ataga, KI., et al. 2007. Br J Haematol. 139: 3-13. PMID: 17854302
- The subcellular localization of the Niemann-Pick Type C proteins depends on the adaptor complex AP-3. | Berger, AC., et al. 2007. J Cell Sci. 120: 3640-52. PMID: 17895371
- Wilms tumour: prognostic factors, staging, therapy and late effects. | Kaste, SC., et al. 2008. Pediatr Radiol. 38: 2-17. PMID: 18026723
- Activation and regulation of ATM kinase activity in response to DNA double-strand breaks. | Lee, JH. and Paull, TT. 2007. Oncogene. 26: 7741-8. PMID: 18066086
- Targeted cancer therapies based on the inhibition of DNA strand break repair. | O'Connor, MJ., et al. 2007. Oncogene. 26: 7816-24. PMID: 18066095
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FRMD8 Antibody (E-11) | sc-514186 | 200 µg/ml | $316.00 | |||
FRMD8 Antibody (E-11): m-IgG Fc BP-HRP Bundle | sc-531057 | 200 µg Ab; 10 µg BP | $354.00 | |||
FRMD8 Antibody (E-11): m-IgGκ BP-HRP Bundle | sc-524640 | 200 µg Ab, 40 µg BP | $354.00 | |||
FRMD8 Antibody (E-11): m-IgG1 BP-HRP Bundle | sc-544377 | 200 µg Ab; 20 µg BP | $354.00 | |||
FRMD8 Antibody (E-11) AC | sc-514186 AC | 500 µg/ml, 25% agarose | $416.00 | |||
FRMD8 Antibody (E-11) HRP | sc-514186 HRP | 200 µg/ml | $316.00 | |||
FRMD8 Antibody (E-11) FITC | sc-514186 FITC | 200 µg/ml | $330.00 | |||
FRMD8 Antibody (E-11) PE | sc-514186 PE | 200 µg/ml | $343.00 | |||
FRMD8 Antibody (E-11) Alexa Fluor® 488 | sc-514186 AF488 | 200 µg/ml | $357.00 | |||
FRMD8 Antibody (E-11) Alexa Fluor® 546 | sc-514186 AF546 | 200 µg/ml | $357.00 | |||
FRMD8 Antibody (E-11) Alexa Fluor® 594 | sc-514186 AF594 | 200 µg/ml | $357.00 | |||
FRMD8 Antibody (E-11) Alexa Fluor® 647 | sc-514186 AF647 | 200 µg/ml | $357.00 | |||
FRMD8 Antibody (E-11) Alexa Fluor® 680 | sc-514186 AF680 | 200 µg/ml | $357.00 | |||
FRMD8 Antibody (E-11) Alexa Fluor® 790 | sc-514186 AF790 | 200 µg/ml | $357.00 | |||
FRMD8 (E-11) Neutralizing Peptide | sc-514186 P | 100 µg/0.5 ml | $68.00 |