fractalkine Antibody (B-1): sc-137046
- fractalkine Antibody (B-1) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against amino acids 98-397 of fractalkine of human origin
- recommended for detection of fractalkine of human origin by WB, IP, IF and ELISA
- m-IgG2b BP-HRP is the preferred secondary detection reagent for fractalkine Antibody (B-1) for WB applications. This reagent is now offered in a bundle with fractalkine Antibody (B-1) (see ordering information below).
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Fractalkine Antibody (B-1) is a mouse monoclonal IgG2b antibody that detects fractalkine in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Fractalkine, also known as neurotactin, plays a crucial role in the immune response and neuronal signaling, acting as both a chemokine and an adhesion molecule. Anti-fractalkine antibody (B-1) recognizes a unique structure featuring a C-X3-C motif, distinguishing fractalkine from other chemokines, which exists in two forms: a membrane-bound variant that facilitates cell adhesion and a soluble form that promotes chemotaxis. The presence of fractalkine in the brain and heart, particularly its upregulation in microglia and endothelial cells during inflammatory responses, underscores its importance in mediating neuroinflammation and vascular responses. Fractalkine monoclonal antibody (B-1) enables researchers to explore fractalkine dynamics in various biological contexts, enhancing our understanding of its role in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
fractalkine Antibody (B-1) References:
- Fractalkine/CX3CR1 is involved in the cross-talk between neuron and glia in neurological diseases. | Luo, P., et al. 2019. Brain Res Bull. 146: 12-21. PMID: 30496784
- Fractalkine/CX3CL1 in Neoplastic Processes. | Korbecki, J., et al. 2020. Int J Mol Sci. 21: PMID: 32466280
- Fractalkine-induced microglial vasoregulation occurs within the retina and is altered early in diabetic retinopathy. | Mills, SA., et al. 2021. Proc Natl Acad Sci U S A. 118: PMID: 34903661
- Fractalkine enhances oligodendrocyte regeneration and remyelination in a demyelination mouse model. | de Almeida, MMA., et al. 2023. Stem Cell Reports. 18: 519-533. PMID: 36608690
- Fractalkine Enhances Hematoma Resolution and Improves Neurological Function via CX3CR1/AMPK/PPARγ Pathway After GMH. | Chen, X., et al. 2023. Stroke. 54: 2420-2433. PMID: 37465997
- Age-dependent changes on fractalkine forms and their contribution to neurodegenerative diseases. | Eugenín, J., et al. 2023. Front Mol Neurosci. 16: 1249320. PMID: 37818457
- Fractalkine isoforms differentially regulate microglia-mediated inflammation and enhance visual function in the diabetic retina. | Rodriguez, D., et al. 2024. J Neuroinflammation. 21: 42. PMID: 38311721
- Therapeutic Delivery of Soluble Fractalkine Ameliorates Vascular Dysfunction in the Diabetic Retina. | Rodriguez, D., et al. 2024. Int J Mol Sci. 25: PMID: 38339005
- CX3CL1 (Fractalkine)-CX3CR1 Axis in Inflammation-Induced Angiogenesis and Tumorigenesis. | Szukiewicz, D. 2024. Int J Mol Sci. 25: PMID: 38731899
- Fractalkine in Health and Disease. | Rodriguez, C., et al. 2024. Int J Mol Sci. 25: PMID: 39125578
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
fractalkine Antibody (B-1) | sc-137046 | 200 µg/ml | $322.00 | |||
fractalkine Antibody (B-1): m-IgG2b BP-HRP Bundle | sc-548500 | 200 µg Ab; 10 µg BP | $361.00 |