fractalkine Antibody (A-9): sc-166200

Fractalkine Antibody (A-9) is a mouse monoclonal IgG3 kappa light chain antibody that detects the fractalkine protein of human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-fractalkine antibody (A-9) is available as the non-conjugated form. Fractalkine, also known as CX3CL1 or neurotactin, plays a crucial role in immune response and neuronal signaling, acting as both a chemokine and adhesion molecule. A unique structure featuring a C-X3-C motif distinguishes fractalkine from other chemokines and allows existence in both membrane-bound and soluble forms. Membrane-bound fractalkine mediates interactions between neurons and immune cells, facilitating monocyte and T cell recruitment to inflammation sites. This dual functionality underscores fractalkine′s significance in neuroinflammatory processes and immune response regulation, making fractalkine a vital target for research in neurodegenerative diseases and inflammatory conditions. Fractalkine mRNA expression occurs in brain and heart, with notable upregulation in microglia and endothelial cells in response to inflammatory stimuli, highlighting fractalkine′s role in disease pathophysiology.

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fractalkine Antibody (A-9) References:

1. Biology and biochemistry of the chemokines: a family of chemotactic and inflammatory cytokines.  |  Miller, MD. and Krangel, MS. 1992. Crit Rev Immunol. 12: 17-46. PMID: 1418604
2. Properties of the novel proinflammatory supergene 'intercrine' cytokine family.  |  Oppenheim, JJ., et al. 1991. Annu Rev Immunol. 9: 617-48. PMID: 1910690
3. Neuroinflammation and fractalkine signaling in Alzheimer's disease.  |  Finneran, DJ. and Nash, KR. 2019. J Neuroinflammation. 16: 30. PMID: 30744705
4. Fractalkine (CX3CL1) signaling and neuroinflammation in Parkinson's disease: Potential clinical and therapeutic implications.  |  Angelopoulou, E., et al. 2020. Pharmacol Res. 158: 104930. PMID: 32445958
5. Fractalkine-Dependent Microglial Pruning of Viable Oligodendrocyte Progenitor Cells Regulates Myelination.  |  Nemes-Baran, AD., et al. 2020. Cell Rep. 32: 108047. PMID: 32814050
6. Fractalkine/CX3CR1-Dependent Modulation of Synaptic and Network Plasticity in Health and Disease.  |  Camacho-Hernández, NP. and Peña-Ortega, F. 2023. Neural Plast. 2023: 4637073. PMID: 36644710
7. Anti-CX3CL1 (fractalkine) monoclonal antibody attenuates lung and skin fibrosis in sclerodermatous graft-versus-host disease mouse model.  |  Hasegawa, T., et al. 2024. Arthritis Res Ther. 26: 94. PMID: 38702742
8. Review of the chemokine meeting the Third International Symposium of Chemotactic Cytokines.  |  Taub, DD. and Oppenheim, JJ. 1993. Cytokine. 5: 175-9. PMID: 8218927
9. Beta chemokines costimulate lymphocyte cytolysis, proliferation, and lymphokine production.  |  Taub, DD., et al. 1996. J Leukoc Biol. 59: 81-9. PMID: 8558072

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-fractalkine Antibody (A-9) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-fractalkine Antibody (A-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

fractalkine Antibody (A-9) Specifications

Alternate Product Name: CX3CL1

Product Clone Name: A-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 25-100

Epitope Target: fractalkine

Epitope Species: human

Product Reactivity/Detection: fractalkine

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for fractalkine Antibody (A-9): N/A