FOXRED1 Antibody (H-9): sc-377264
- FOXRED1 Antibody (H-9) is a mouse monoclonal IgG2b κ FOXRED1 antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 333-367 within an internal region of FOXRED1 of human origin
- FOXRED1 Antibody (H-9) is recommended for detection of FOXRED1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-FOXRED1 Antibody (H-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for FOXRED1 Antibody (H-9) for WB applications. These reagents are now offered in bundles with FOXRED1 Antibody (H-9) (see ordering information below).
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FOXRED1 Antibody (H-9) is a mouse monoclonal IgG2b kappa light chain antibody that detects FOXRED1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FOXRED1 (H-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FOXRED1, also known as FAD-dependent oxidoreductase domain-containing protein 1 or FP634, is a 486 amino acid single-pass membrane protein that plays a crucial role in mitochondrial function. Specifically, FOXRED1 utilizes flavin adenine dinucleotide (FAD) as a cofactor and acts as a chaperone protein essential for proper functioning of mitochondrial complex I. This is particularly important because mitochondrial complex I is a key component of the electron transport chain, vital for ATP production and cellular energy metabolism. Mutations in FOXRED1 can lead to mitochondrial complex I deficiency (MT-C1D), resulting in a spectrum of clinical manifestations ranging from severe neonatal diseases to adult-onset neurodegenerative disorders. Common phenotypes associated with MT-C1D include cardiomyopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and certain forms of Parkinson′s disease. FOXRED1 exists as three alternatively spliced isoforms and is encoded by a gene located on human chromosome 11q24.2, a region known for its density of gene and disease associations, comprising approximately 135 million base pairs and 1,400 genes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
FOXRED1 Antibody (H-9) References:
- Identification of differentially expressed genes associated with HER-2/neu overexpression in human breast cancer cells. | Oh, JJ., et al. 1999. Nucleic Acids Res. 27: 4008-17. PMID: 10497265
- Leigh syndrome associated with mitochondrial complex I deficiency due to a novel mutation in the NDUFS1 gene. | Martín, MA., et al. 2005. Arch Neurol. 62: 659-61. PMID: 15824269
- Mice with mitochondrial complex I deficiency develop a fatal encephalomyopathy. | Kruse, SE., et al. 2008. Cell Metab. 7: 312-20. PMID: 18396137
- Mitochondrial complex I deficiency: from organelle dysfunction to clinical disease. | Distelmaier, F., et al. 2009. Brain. 132: 833-42. PMID: 19336460
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. | Bailey, SD., et al. 2010. Diabetes Care. 33: 2250-3. PMID: 20628086
- High-throughput, pooled sequencing identifies mutations in NUBPL and FOXRED1 in human complex I deficiency. | Calvo, SE., et al. 2010. Nat Genet. 42: 851-8. PMID: 20818383
- FOXRED1, encoding an FAD-dependent oxidoreductase complex-I-specific molecular chaperone, is mutated in infantile-onset mitochondrial encephalopathy. | Fassone, E., et al. 2010. Hum Mol Genet. 19: 4837-47. PMID: 20858599
- Cellular rescue-assay aids verification of causative DNA-variants in mitochondrial complex I deficiency. | Danhauser, K., et al. 2011. Mol Genet Metab. 103: 161-6. PMID: 21458341
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FOXRED1 Antibody (H-9) | sc-377264 | 200 µg/ml | $322.00 | |||
FOXRED1 Antibody (H-9): m-IgGκ BP-HRP Bundle | sc-523255 | 200 µg Ab, 40 µg BP | $361.00 | |||
FOXRED1 Antibody (H-9): m-IgG2b BP-HRP Bundle | sc-549100 | 200 µg Ab; 10 µg BP | $361.00 | |||
FOXRED1 Antibody (H-9) AC | sc-377264 AC | 500 µg/ml, 25% agarose | $424.00 | |||
FOXRED1 Antibody (H-9) HRP | sc-377264 HRP | 200 µg/ml | $322.00 | |||
FOXRED1 Antibody (H-9) FITC | sc-377264 FITC | 200 µg/ml | $336.00 | |||
FOXRED1 Antibody (H-9) PE | sc-377264 PE | 200 µg/ml | $349.00 | |||
FOXRED1 Antibody (H-9) Alexa Fluor® 488 | sc-377264 AF488 | 200 µg/ml | $364.00 | |||
FOXRED1 Antibody (H-9) Alexa Fluor® 546 | sc-377264 AF546 | 200 µg/ml | $364.00 | |||
FOXRED1 Antibody (H-9) Alexa Fluor® 594 | sc-377264 AF594 | 200 µg/ml | $364.00 | |||
FOXRED1 Antibody (H-9) Alexa Fluor® 647 | sc-377264 AF647 | 200 µg/ml | $364.00 | |||
FOXRED1 Antibody (H-9) Alexa Fluor® 680 | sc-377264 AF680 | 200 µg/ml | $364.00 | |||
FOXRED1 Antibody (H-9) Alexa Fluor® 790 | sc-377264 AF790 | 200 µg/ml | $364.00 | |||
FOXRED1 (H-9) Neutralizing Peptide | sc-377264 P | 100 µg/0.5 ml | $69.00 |