FOXJ1 Antibody (B-8): sc-365216

FOXJ1 Antibody (B-8) is a mouse monoclonal IgG1 antibody that detects Forkhead-box J1 (FOXJ1) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FOXJ1 is a crucial 421-amino acid transcription factor that plays a significant role in regulating immune responses by suppressing T cell activity and inhibiting the humoral immune response in B cells. This regulation is vital for preventing spontaneous autoimmunity, as FOXJ1 deficiency in B cells can lead to excessive germinal center formation, which is linked to the development of pathogenic autoantibodies and heightened responses to immunizations. Additionally, FOXJ1 is essential for cilia formation and the determination of left-right axis in developing embryos, as FOXJ1 enhances the expression of calpastatin, a protein necessary for the anchoring of basal bodies to the apical cytoskeleton. FOXJ1 expression may also serve as an early marker for epithelial cell differentiation, recovery, and overall function, making FOXJ1 a significant protein in both developmental biology and immunology. Anti-FOXJ1 antibody (B-8) is an invaluable tool for researchers investigating the complex roles of FOXJ1 in health and disease.

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FOXJ1 Antibody (B-8) References:

1. Foxj1 regulates basal body anchoring to the cytoskeleton of ciliated pulmonary epithelial cells.  |  Gomperts, BN., et al. 2004. J Cell Sci. 117: 1329-37. PMID: 14996907
2. Novel expression and transcriptional regulation of FoxJ1 during oro-facial morphogenesis.  |  Venugopalan, SR., et al. 2008. Hum Mol Genet. 17: 3643-54. PMID: 18723525
3. Expression of FOXJ1 in hepatocellular carcinoma: correlation with patients' prognosis and tumor cell proliferation.  |  Chen, HW., et al. 2013. Mol Carcinog. 52: 647-59. PMID: 22488567
4. The expression of FOXJ1 in neurogenesis after transient focal cerebral ischemia.  |  Huang, Y., et al. 2013. Can J Neurol Sci. 40: 403-9. PMID: 23603178
5. RFX3 modulation of FOXJ1 regulation of cilia genes in the human airway epithelium.  |  Didon, L., et al. 2013. Respir Res. 14: 70. PMID: 23822649
6. Decreased expression of FOXJ1 is a potential prognostic predictor for progression and poor survival of gastric cancer.  |  Wang, J., et al. 2015. Ann Surg Oncol. 22: 685-92. PMID: 24809300
7. Decreased FOXJ1 expression and its ciliogenesis programme in aggressive ependymoma and choroid plexus tumours.  |  Abedalthagafi, MS., et al. 2016. J Pathol. 238: 584-97. PMID: 26690880
8. Significance of the detection of TIM-3 and FOXJ1 in prostate cancer.  |  Lan, Y., et al. 2017. J BUON. 22: 1017-1021. PMID: 28952222
9. FoxJ1 regulates spinal cord development and is required for the maintenance of spinal cord stem cell potential.  |  Li, X., et al. 2018. Exp Cell Res. 368: 84-100. PMID: 29689278
10. Persistence of FoxJ1+ Pax6+ Sox2+ ependymal cells throughout life in the human spinal cord.  |  Ripoll, C., et al. 2023. Cell Mol Life Sci. 80: 181. PMID: 37329342

The preferred FOXJ1 antibody is FOXJ1 Antibody (3-19): sc-53139.