FOXJ1 Antibody (3-19): sc-53139

FOXJ1 Antibody (3-19) is a mouse monoclonal IgG1 kappa light chain antibody that detects FOXJ1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. FOXJ1 Antibody (3-19) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The Forkhead-box J1 (FOXJ1) protein, consisting of 421 amino acids, plays a crucial role as a transcription factor that regulates immune responses by suppressing T cell activity and inhibiting the humoral immune response in B cells. FOXJ1 prevents spontaneous autoimmunity by repressing NFκB activity, which is often implicated in inflammatory processes. Additionally, FOXJ1 is essential for cilia formation and left-right axis determination, as FOXJ1 enhances the expression of calpastatin, a protein necessary for the anchoring of basal bodies to the apical cytoskeleton. FOXJ1 expression may serve as an early marker for epithelial cell differentiation, recovery, and function, and abnormal FOXJ1 expression has been linked to autoimmune diseases and other inflammatory conditions. With diverse applications and critical role in immune regulation and cellular processes, anti-FOXJ1 antibody (3-19) serves as an invaluable tool for researchers studying these complex biological pathways.

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FOXJ1 Antibody (3-19) References:

1. Effects of paramyxoviral infection on airway epithelial cell Foxj1 expression, ciliogenesis, and mucociliary function.  |  Look, DC., et al. 2001. Am J Pathol. 159: 2055-69. PMID: 11733356
2. Foxj1 is required for apical localization of ezrin in airway epithelial cells.  |  Huang, T., et al. 2003. J Cell Sci. 116: 4935-45. PMID: 14625387
3. Foxj1 regulates basal body anchoring to the cytoskeleton of ciliated pulmonary epithelial cells.  |  Gomperts, BN., et al. 2004. J Cell Sci. 117: 1329-37. PMID: 14996907
4. Foxj1 regulates asymmetric gene expression during left-right axis patterning in mice.  |  Zhang, M., et al. 2004. Biochem Biophys Res Commun. 324: 1413-20. PMID: 15504371
5. Restraint of B cell activation by Foxj1-mediated antagonism of NF-kappa B and IL-6.  |  Lin, L., et al. 2005. J Immunol. 175: 951-8. PMID: 16002694
6. Roles of the Foxj1 and Inv genes in the left-right determination of internal organs in mice.  |  Tamakoshi, T., et al. 2006. Biochem Biophys Res Commun. 339: 932-8. PMID: 16325766
7. Cutting edge: Foxj1 protects against autoimmunity and inhibits thymocyte egress.  |  Srivatsan, S. and Peng, SL. 2005. J Immunol. 175: 7805-9. PMID: 16339515
8. Developmental expression of FoxJ1.2, FoxJ2, and FoxQ1 in Xenopus tropicalis.  |  Choi, VM., et al. 2006. Gene Expr Patterns. 6: 443-7. PMID: 16461016
9. Identification of single nucleotide polymorphisms in FOXJ1 and their association with allergic rhinitis.  |  Li, CS., et al. 2006. J Hum Genet. 51: 292-297. PMID: 16518568
10. Knockdown of FOXJ1 inhibits the proliferation, migration, invasion, and glycolysis in laryngeal squamous cell carcinoma cells.  |  Liu, L., et al. 2019. J Cell Biochem. 120: 15874-15882. PMID: 31062413
11. Heterozygous FOXJ1 Mutations Cause Incomplete Ependymal Cell Differentiation and Communicating Hydrocephalus.  |  Hou, CC., et al. 2023. Cell Mol Neurobiol. 43: 4103-4116. PMID: 37620636
12. The forkhead transcription factor Foxj1 controls vertebrate olfactory cilia biogenesis and sensory neuron differentiation.  |  Rayamajhi, D., et al. 2024. PLoS Biol. 22: e3002468. PMID: 38271330

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FOXJ1 Antibody (3-19) has 13 citations in a variety of scientific publications.

Primary antibodies like Anti-FOXJ1 Antibody (3-19) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FOXJ1 Antibody (3-19) Specifications

Alternate Product Name: FOXJ1

Product Clone Name: 3-19

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: FOXJ1

Epitope Species: rat

Product Reactivity/Detection: FOXJ1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 13 citations in various scientific publications

Available Conjugates/Forms for FOXJ1 Antibody (3-19): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin