folliculin Antibody (D-4): sc-271558
- folliculin Antibody (D-4) is a mouse monoclonal IgG1 κ folliculin antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 555-579 at the C-terminus of folliculin of human origin
- folliculin Antibody (D-4) is recommended for detection of folliculin of human origin by WB, IP, IF and ELISA
- Anti-folliculin Antibody (D-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for folliculin Antibody (D-4) for WB applications. These reagents are now offered in bundles with folliculin Antibody (D-4) (see ordering information below).
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Folliculin Antibody (D-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects folliculin protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-folliculin antibody (D-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Folliculin protein plays a crucial role in cellular signaling pathways, particularly in the regulation of mTOR (mechanistic target of rapamycin) signaling, which is essential for cell growth, proliferation, and survival. Dysregulation of mTOR signaling is implicated in various diseases, including cancer, making folliculin studies particularly important in understanding tumorigenesis. Birt-Hogg-Dubé (BHD) syndrome, a rare autosomal dominant cancer syndrome associated with mutations in the folliculin gene, is characterized by kidney tumors, benign hair follicle tumors, and spontaneous pneumothorax. The BHD gene is located on chromosome 17p11.2 and is widely expressed in tissues such as the kidney, lung, and skin, where BHD tumors typically arise. The (C)8 tract in exon 11 of the folliculin gene is a mutational hotspot, and BHD syndrome exhibits reduced penetrance or late onset, with studies showing a mean of 5.3 renal tumors per patient among 30 BHD patients, highlighting the importance of early detection and monitoring in affected individuals.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
folliculin Antibody (D-4) References:
- Birt-Hogg-Dubé syndrome, a genodermatosis associated with spontaneous pneumothorax and kidney neoplasia, maps to chromosome 17p11.2. | Schmidt, LS., et al. 2001. Am J Hum Genet. 69: 876-82. PMID: 11533913
- Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dubé syndrome. | Nickerson, ML., et al. 2002. Cancer Cell. 2: 157-64. PMID: 12204536
- Renal tumors in the Birt-Hogg-Dubé syndrome. | Pavlovich, CP., et al. 2002. Am J Surg Pathol. 26: 1542-52. PMID: 12459621
- Clinical and genetic studies of Birt-Hogg-Dubé syndrome. | Khoo, SK., et al. 2002. J Med Genet. 39: 906-12. PMID: 12471204
- Lack of mutation of the folliculin gene in sporadic chromophobe renal cell carcinoma and renal oncocytoma. | Nagy, A., et al. 2004. Int J Cancer. 109: 472-5. PMID: 14961590
- Expression of Birt-Hogg-Dubé gene mRNA in normal and neoplastic human tissues. | Warren, MB., et al. 2004. Mod Pathol. 17: 998-1011. PMID: 15143337
- [Fibrofolliculoma, trichodiscoma and acrochordon. The Birt-Hogg-Dubé syndrome]. | Balus, L., et al. 1983. Ann Dermatol Venereol. 110: 601-9. PMID: 6660760
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
folliculin Antibody (D-4) | sc-271558 | 200 µg/ml | $322.00 | |||
folliculin Antibody (D-4): m-IgG Fc BP-HRP Bundle | sc-529211 | 200 µg Ab; 10 µg BP | $361.00 | |||
folliculin Antibody (D-4): m-IgGκ BP-HRP Bundle | sc-521980 | 200 µg Ab, 40 µg BP | $361.00 | |||
folliculin Antibody (D-4): m-IgG1 BP-HRP Bundle | sc-543389 | 200 µg Ab; 20 µg BP | $361.00 | |||
folliculin Antibody (D-4) AC | sc-271558 AC | 500 µg/ml, 25% agarose | $424.00 | |||
folliculin Antibody (D-4) HRP | sc-271558 HRP | 200 µg/ml | $322.00 | |||
folliculin Antibody (D-4) FITC | sc-271558 FITC | 200 µg/ml | $336.00 | |||
folliculin Antibody (D-4) PE | sc-271558 PE | 200 µg/ml | $349.00 | |||
folliculin Antibody (D-4) Alexa Fluor® 488 | sc-271558 AF488 | 200 µg/ml | $364.00 | |||
folliculin Antibody (D-4) Alexa Fluor® 546 | sc-271558 AF546 | 200 µg/ml | $364.00 | |||
folliculin Antibody (D-4) Alexa Fluor® 594 | sc-271558 AF594 | 200 µg/ml | $364.00 | |||
folliculin Antibody (D-4) Alexa Fluor® 647 | sc-271558 AF647 | 200 µg/ml | $364.00 | |||
folliculin Antibody (D-4) Alexa Fluor® 680 | sc-271558 AF680 | 200 µg/ml | $364.00 | |||
folliculin Antibody (D-4) Alexa Fluor® 790 | sc-271558 AF790 | 200 µg/ml | $364.00 | |||
folliculin (D-4) Neutralizing Peptide | sc-271558 P | 100 µg/0.5 ml | $69.00 |