FMO5 Antibody (E-8): sc-393732
- FMO5 Antibody (E-8) is a mouse monoclonal IgG1 κ FMO5 antibody provided at 200 µg/ml
- raised against amino acids 398-455 mapping within an internal region of FMO5 of human origin
- FMO5 Antibody (E-8) is recommended for detection of FMO5 of human origin by WB, IP, IF and ELISA
- Anti-FMO5 Antibody (E-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for FMO5 Antibody (E-8) for WB applications. These reagents are now offered in bundles with FMO5 Antibody (E-8) (see ordering information below).
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FMO5 Antibody (E-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects FMO5 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-FMO5 antibody (E-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FMO5, also known as dimethylaniline monooxygenase [N-oxide-forming] 5, is a 533 amino acid enzyme that plays a crucial role in xenobiotic metabolism, although FMO5 does not function as a drug-metabolizing enzyme like its FMO family counterparts. Localized primarily in microsomal and endoplasmic reticulum membranes, FMO5 is expressed in both adult and fetal liver tissues and is unique among flavin-containing monooxygenases due to specific binding of flavin adenine dinucleotide (FAD) as a cofactor. FMO5 is encoded by a gene located on human chromosome 1q21.1, and FMO5′s distinct function and localization are essential for understanding its role in metabolic processes and potential implications in pharmacogenomics.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
FMO5 Antibody (E-8) References:
- Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism. | Krueger, SK. and Williams, DE. 2005. Pharmacol Ther. 106: 357-87. PMID: 15922018
- The molecular biology of the flavin-containing monooxygenases of man. | Phillips, IR., et al. 1995. Chem Biol Interact. 96: 17-32. PMID: 7720101
- Characterization of flavin-containing monooxygenase 5 (FMO5) cloned from human and guinea pig: evidence that the unique catalytic properties of FMO5 are not confined to the rabbit ortholog. | Overby, LH., et al. 1995. Arch Biochem Biophys. 317: 275-84. PMID: 7872795
- Localization of human flavin-containing monooxygenase genes FMO2 and FMO5 to chromosome 1q. | McCombie, RR., et al. 1996. Genomics. 34: 426-9. PMID: 8786146
- Physical mapping of the human connexin 40 (GJA5), flavin-containing monooxygenase 5, and natriuretic peptide receptor a genes on 1q21. | Gelb, BD., et al. 1997. Genomics. 39: 409-11. PMID: 9119381
- Progesterone regulated expression of flavin-containing monooxygenase 5 by the B-isoform of progesterone receptors: implications for tamoxifen carcinogenicity. | Miller, MM., et al. 1997. J Clin Endocrinol Metab. 82: 2956-61. PMID: 9284726
- Quantitation and kinetic properties of hepatic microsomal and recombinant flavin-containing monooxygenases 3 and 5 from humans. | Overby, LH., et al. 1997. Chem Biol Interact. 106: 29-45. PMID: 9305407
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FMO5 Antibody (E-8) | sc-393732 | 200 µg/ml | $322.00 | |||
FMO5 Antibody (E-8): m-IgG Fc BP-HRP Bundle | sc-530563 | 200 µg Ab; 10 µg BP | $361.00 | |||
FMO5 Antibody (E-8): m-IgGκ BP-HRP Bundle | sc-524069 | 200 µg Ab, 40 µg BP | $361.00 | |||
FMO5 Antibody (E-8): m-IgG1 BP-HRP Bundle | sc-544134 | 200 µg Ab; 20 µg BP | $361.00 | |||
FMO5 Antibody (E-8) AC | sc-393732 AC | 500 µg/ml, 25% agarose | $424.00 | |||
FMO5 Antibody (E-8) HRP | sc-393732 HRP | 200 µg/ml | $322.00 | |||
FMO5 Antibody (E-8) FITC | sc-393732 FITC | 200 µg/ml | $336.00 | |||
FMO5 Antibody (E-8) PE | sc-393732 PE | 200 µg/ml | $349.00 | |||
FMO5 Antibody (E-8) Alexa Fluor® 488 | sc-393732 AF488 | 200 µg/ml | $364.00 | |||
FMO5 Antibody (E-8) Alexa Fluor® 546 | sc-393732 AF546 | 200 µg/ml | $364.00 | |||
FMO5 Antibody (E-8) Alexa Fluor® 594 | sc-393732 AF594 | 200 µg/ml | $364.00 | |||
FMO5 Antibody (E-8) Alexa Fluor® 647 | sc-393732 AF647 | 200 µg/ml | $364.00 | |||
FMO5 Antibody (E-8) Alexa Fluor® 680 | sc-393732 AF680 | 200 µg/ml | $364.00 | |||
FMO5 Antibody (E-8) Alexa Fluor® 790 | sc-393732 AF790 | 200 µg/ml | $364.00 |