Flg/FGFR1 Antibody (M2F12): sc-57132

Flg Antibody (M2F12) is a mouse monoclonal IgG2a kappa light chain antibody that detects the Flg protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-Flg antibody (M2F12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Flg protein, also known as fibroblast growth factor receptor 1, plays a crucial role in cellular signaling pathways that regulate cell proliferation, differentiation, and survival, making Flg essential for normal development and tissue homeostasis. Flg function is vital for various physiological processes, including angiogenesis and wound healing, and dysregulation of Flg can lead to pathological conditions such as cancer and fibrosis. Understanding Flg interactions with specific proteins, such as fibroblast growth factors, is important for elucidating Flg role in these processes and developing targeted therapies. Flg (M2F12) antibody is an invaluable tool for researchers investigating the complex mechanisms of cell signaling and the implications of Flg in health and disease.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Flg/FGFR1 Antibody (M2F12) References:

1. Fusion of the BCR and the fibroblast growth factor receptor-1 (FGFR1) genes as a result of t(8;22)(p11;q11) in a myeloproliferative disorder: the first fusion gene involving BCR but not ABL.  |  Fioretos, T., et al. 2001. Genes Chromosomes Cancer. 32: 302-10. PMID: 11746971
2. Characterization of the murine BEK fibroblast growth factor (FGF) receptor: activation by three members of the FGF family and requirement for heparin.  |  Mansukhani, A., et al. 1992. Proc Natl Acad Sci U S A. 89: 3305-9. PMID: 1373495
3. Identification of a novel gene, FGFR1OP2, fused to FGFR1 in 8p11 myeloproliferative syndrome.  |  Grand, EK., et al. 2004. Genes Chromosomes Cancer. 40: 78-83. PMID: 15034873
4. Autophosphorylation of FGFR1 kinase is mediated by a sequential and precisely ordered reaction.  |  Furdui, CM., et al. 2006. Mol Cell. 21: 711-7. PMID: 16507368
5. Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.  |  Dionne, CA., et al. 1990. EMBO J. 9: 2685-92. PMID: 1697263
6. Recent developments in the cell biology of basic fibroblast growth factor.  |  Rifkin, DB. and Moscatelli, D. 1989. J Cell Biol. 109: 1-6. PMID: 2545723
7. Clinical outcomes of myeloid/lymphoid neoplasms with fibroblast growth factor receptor-1 (FGFR1) rearrangement.  |  Umino, K., et al. 2018. Hematology. 23: 470-477. PMID: 29486661
8. Mr 25,000 heparin-binding protein from guinea pig brain is a high molecular weight form of basic fibroblast growth factor.  |  Moscatelli, D., et al. 1987. Proc Natl Acad Sci U S A. 84: 5778-82. PMID: 3475702
9. Fibroblast growth factor receptor 1/Klothoβ agonist BFKB8488A improves lipids and liver health markers in patients with diabetes or NAFLD: A phase 1b randomized trial.  |  Wong, C., et al. 2023. Hepatology. 78: 847-862. PMID: 35993161
10. A selective Fibroblast Growth Factor Receptor 1/2 PROTAC degrader with antitumor activity.  |  Kong, Y., et al. 2024. Mol Cancer Ther.. PMID: 38647531
11. A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome.  |  Muenke, M., et al. 1994. Nat Genet. 8: 269-74. PMID: 7874169
12. Cloning and expression of fibroblast growth factor receptor-1 isoforms in the mouse heart: evidence for isoform switching during heart development.  |  Jin, Y., et al. 1994. J Mol Cell Cardiol. 26: 1449-59. PMID: 7897669

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Flg/FGFR1 Antibody (M2F12) has 24 citations in a variety of scientific publications.

Primary antibodies like Anti-Flg/FGFR1 Antibody (M2F12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Flg/FGFR1 Antibody (M2F12) Specifications

Alternate Product Name: Flg

Product Clone Name: M2F12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids:

Epitope Target: Flg isoform α

Epitope Species: human

Product Reactivity/Detection: Flg isoform α

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 24 citations in various scientific publications

Available Conjugates/Forms for Flg/FGFR1 Antibody (M2F12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin