Fis1 Antibody (D-9): sc-376446

Fis1 Antibody (D-9) is a mouse monoclonal IgG2b antibody that detects Fis1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Fis1 monoclonal antibody (D-9) is raised against amino acids 1-152 representing full length Fis1 of human origin. Anti-Fis1 antibody (D-9) plays a crucial role in studying mitochondrial dynamics, specifically in the process of mitochondrial fission, which is essential for maintaining cellular health and function. Located on the outer mitochondrial membrane, Fis1 interacts with dynamin-related protein 1 (Drp1) to facilitate the division of mitochondria, a process vital for energy production and apoptosis regulation. Proper functioning of Fis1 is critical, as dysregulation can lead to altered mitochondrial morphology and contribute to various diseases, including neurodegenerative disorders and cancer. The C-terminal domain of Fis1 is essential for mitochondrial localization, while the N-terminal domain is necessary for fission activity, highlighting the importance of structural integrity in cellular processes. Fis1 monoclonal antibody (D-9) serves as an invaluable tool for researchers studying mitochondrial dynamics and their implications in health and disease.

The preferred Fis1 antibody is Fis1 Antibody (B-5): sc-376447.