Fis1 Activators
Fis1, short for Mitochondrial fission 1 protein, is a pivotal component in the process of mitochondrial fission, which plays a significant role in ensuring the proper function, distribution, and health of mitochondria within cells. This process is vital because it allows the separation of damaged mitochondrial parts, enabling the cell to segregate and eventually degrade them, ensuring mitochondrial health and function. Fis1 serves as an essential adaptor protein that helps in recruiting other elements of the fission machinery to the outer mitochondrial membrane, facilitating the fission process.
The class of compounds known as Fis1 Activators directly or indirectly stimulates the activity of the Fis1 protein. The molecular mechanisms of these activators can be diverse, ranging from direct interaction with Fis1, which might enhance its recruitment capability or its ability to interact with other fission proteins, to modulating intracellular pathways that indirectly bolster Fis1 function. By enhancing Fis1 activity, these activators can drive the fission process more effectively, ensuring that mitochondria within the cells are maintained in a healthier state, with damaged or dysfunctional portions being efficiently isolated and targeted for degradation. Understanding the structure and function of these activators provides invaluable insight into the intricate regulation of mitochondrial dynamics, emphasizing the profound importance of maintaining mitochondrial health for overall cellular function and vitality.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Mdivi-1 | 338967-87-6 | sc-215291 sc-215291B sc-215291A sc-215291C | 5 mg 10 mg 25 mg 50 mg | $67.00 $126.00 $251.00 $465.00 | 13 | |
Inhibitor of Drp1 (a protein that interacts with FIS1 for mitochondrial fission). The exact mechanism of how it might affect FIS1 expression is not clear. | ||||||
Carbonyl Cyanide m-Chlorophenylhydrazone | 555-60-2 | sc-202984A sc-202984 sc-202984B | 100 mg 250 mg 500 mg | $77.00 $153.00 $240.00 | 8 | |
Uncoupling agent that disrupts mitochondrial membrane potential. This can lead to increased mitochondrial fission and possibly influence FIS1 expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Has been shown to influence mitochondrial dynamics and biogenesis, though its specific effect on FIS1 expression needs further investigation. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
Known to activate AMPK and influence mitochondrial function. It's unclear if it directly induces FIS1 expression. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
Antioxidant that might protect mitochondrial function. Its direct role in FIS1 expression is not clear. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
ER stress inducer. ER-mitochondrial interactions might affect FIS1 expression. | ||||||
Valinomycin | 2001-95-8 | sc-200991 | 25 mg | $250.00 | 3 | |
A potassium-selective ionophore that disrupts mitochondrial membrane potential. This can potentially influence mitochondrial dynamics and FIS1 expression. | ||||||