Filamin 3 Antibody (D-6): sc-166484

Filamin 3 Antibody (D-6) is a mouse monoclonal IgG1 antibody that detects Filamin 3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Filamin 3, also known as Filamin B or β-Filamin, is a crucial actin-binding protein that plays a significant role in the structural organization of the cytoskeleton, particularly during endochondral ossification, vertebral segmentation, and joint formation. Anti-Filamin 3 antibody (D-6) recognizes flexible cross-links between actin filaments vital for maintaining membrane integrity under mechanical stress, which is essential for cellular stability and function. Additionally, Filamin 3 interacts with other proteins, including Filamin 1, facilitating neuroblast migration into the cortical plate from the ventricular zone, a process critical for proper brain development. Mutations in the FLNB gene, which encodes Filamin 3, have been linked to several skeletal disorders, such as autosomal dominant Larsen syndrome and spondylocarpotarsal syndrome, as well as the neurological disorder periventricular heterotopia, highlighting the importance of this protein in both skeletal and neural development. Filamin 3 (D-6) monoclonal antibody serves as an invaluable tool for researchers studying these pathways and disorders, providing reliable detection and analysis of this essential protein.

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Filamin 3 Antibody (D-6) References:

1. Complex roles of filamin-A mediated cytoskeleton network in cancer progression.  |  Yue, J., et al. 2013. Cell Biosci. 3: 7. PMID: 23388158
2. Gene methylation in gastric cancer.  |  Qu, Y., et al. 2013. Clin Chim Acta. 424: 53-65. PMID: 23669186
3. Filamin C, a dysregulated protein in cancer revealed by label-free quantitative proteomic analyses of human gastric cancer cells.  |  Qiao, J., et al. 2015. Oncotarget. 6: 1171-89. PMID: 25577646
4. ATPR-induced G0 /G1 phase arrest in gastric cancer cells by regulating the binding of 14-3-3ε and filamin A.  |  Zhao, Y., et al. 2018. Cancer Med. 7: 3373-3384. PMID: 29862660
5. Silencing Filamin A Inhibits the Invasion and Migration of Breast Cancer Cells by Up-regulating 14-3-3σ.  |  Ji, ZM., et al. 2018. Curr Med Sci. 38: 461-466. PMID: 30074213
6. Disrupted filamin A/αIIbβ3 interaction induces macrothrombocytopenia by increasing RhoA activity.  |  Donada, A., et al. 2019. Blood. 133: 1778-1788. PMID: 30602618
7. Non-Phosphorylatable PEA-15 Sensitises SKOV-3 Ovarian Cancer Cells to Cisplatin.  |  Dilruba, S., et al. 2020. Cells. 9: PMID: 32102425
8. Involvement of Actin and Actin-Binding Proteins in Carcinogenesis.  |  Izdebska, M., et al. 2020. Cells. 9: PMID: 33036298
9. Methylation-Mediated Silencing of ATF3 Promotes Thyroid Cancer Progression by Regulating Prognostic Genes in the MAPK and PI3K/AKT Pathways.  |  Xiao, X., et al. 2023. Thyroid. 33: 1441-1454. PMID: 37742107
10. CSNK2 suppresses autophagy by activating FLN-NHL-containing TRIM proteins.  |  Hoenigsperger, H., et al. 2024. Autophagy. 20: 994-1014. PMID: 37938186

The preferred Filamin 3 antibody is Filamin 3 Antibody (F-8): sc-376241.