Filamin 3 Antibody (B-7): sc-166671

Filamin 3 Antibody (B-7) is a mouse monoclonal IgG2b antibody that detects Filamin 3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Filamin 3, also known as Filamin B or β-Filamin, is crucial for maintaining the structural integrity of the cytoskeleton by forming flexible cross-links between actin filaments, which is essential for cellular shape and mechanical stability. Filamin 3 is predominantly located in the cytoplasm and is particularly important during processes such as endochondral ossification, vertebral segmentation, and joint formation. Filamin 3 localization is vital for facilitating neuroblast migration into the cortical plate from the ventricular zone, a process that is critical for brain development. Mutations in the gene encoding Filamin 3, FLNB, have been linked to several skeletal disorders, including autosomal dominant Larsen syndrome and spondylocarpotarsal syndrome, as well as the neurological disorder periventricular heterotopia, highlighting Filamin 3′s importance in both skeletal and neural development. Anti-Filamin 3 antibody (B-7) is an invaluable tool for researchers studying the intricate roles of Filamin 3 in cellular dynamics and disease mechanisms.

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Filamin 3 Antibody (B-7) References:

1. Differential expression of filamin A and its clinical significance in breast cancer.  |  Tian, HM., et al. 2013. Oncol Lett. 6: 681-686. PMID: 24137390
2. Filamin A regulates MMP-9 expression and suppresses prostate cancer cell migration and invasion.  |  Sun, GG., et al. 2014. Tumour Biol. 35: 3819-26. PMID: 24390612
3. Validation of proposed prostate cancer biomarkers with gene expression data: a long road to travel.  |  Amaro, A., et al. 2014. Cancer Metastasis Rev. 33: 657-71. PMID: 24477410
4. Transcription of Nrdp1 by the androgen receptor is regulated by nuclear filamin A in prostate cancer.  |  Savoy, RM., et al. 2015. Endocr Relat Cancer. 22: 369-86. PMID: 25759396
5. Filamin A phosphorylation by Akt promotes cell migration in response to arsenic.  |  Li, L., et al. 2015. Oncotarget. 6: 12009-19. PMID: 25944616
6. High-level secretion of tissue factor-rich extracellular vesicles from ovarian cancer cells mediated by filamin-A and protease-activated receptors.  |  Koizume, S., et al. 2016. Thromb Haemost. 115: 299-310. PMID: 26446354
7. Glycosylphosphatidylinositol Anchor Modification Machinery Deficiency Is Responsible for the Formation of Pro-Prion Protein (PrP) in BxPC-3 Protein and Increases Cancer Cell Motility.  |  Yang, L., et al. 2016. J Biol Chem. 291: 3905-17. PMID: 26683373
8. Signaling regulation and role of filamin A cleavage in Ca2+-stimulated migration of androgen receptor-deficient prostate cancer cells.  |  Huang, C., et al. 2017. Oncotarget. 8: 3840-3853. PMID: 27206800
9. Identification of Filamin-A and -B as potential biomarkers for prostate cancer.  |  Narain, NR., et al. 2017. Future Sci OA. 3: FSO161. PMID: 28344825
10. Correction to: The androgen receptor/filamin A complex as a target in prostate cancer microenvironment.  |  Di Donato, M., et al. 2021. Cell Death Dis. 12: 272. PMID: 33723231

The preferred Filamin 3 antibody is Filamin 3 Antibody (F-8): sc-376241.