Filamin 3 Antibody (A-4): sc-271698
- Filamin 3 Antibody (A-4) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against amino acids 386-450 mapping within an internal region of Filamin 3 of human origin
- recommended for detection of Filamin 3 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Filamin 3 Antibody (A-4) for WB applications. These reagents are now offered in bundles with Filamin 3 Antibody (A-4) (see ordering information below).
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Filamin 3 Antibody (A-4) is a mouse monoclonal IgG2a antibody that detects Filamin 3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Filamin 3, also known as Filamin B or β-Filamin, is a crucial actin-binding protein that plays a significant role in the structural organization of the cytoskeleton, particularly during endochondral ossification, vertebral segmentation, and joint formation. Filamin 3′s ability to form flexible cross-links between actin filaments is vital for maintaining cellular integrity and facilitating cellular responses to mechanical stress. Additionally, Filamin 3 interacts with Filamin 1, which is essential for neuroblast migration into the cortical plate from the ventricular zone, highlighting Filamin 3′s importance in neurodevelopment. Mutations in the FLNB gene, which encodes Filamin 3, are linked to several skeletal disorders, including autosomal dominant Larsen syndrome and spondylocarpotarsal syndrome, as well as the neurological disorder periventricular heterotopia. Anti-Filamin 3 antibody (A-4) is an invaluable tool for researchers studying these critical biological processes and their implications in health and disease.
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Filamin 3 Antibody (A-4) References:
- Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits. | van der Flier, A., et al. 2002. J Cell Biol. 156: 361-76. PMID: 11807098
- Filamin A and Filamin B are co-expressed within neurons during periods of neuronal migration and can physically interact. | Sheen, VL., et al. 2002. Hum Mol Genet. 11: 2845-54. PMID: 12393796
- Filamin B serves as a molecular scaffold for type I interferon-induced c-Jun NH2-terminal kinase signaling pathway. | Jeon, YJ., et al. 2008. Mol Biol Cell. 19: 5116-30. PMID: 18815275
- Disease-associated substitutions in the filamin B actin binding domain confer enhanced actin binding affinity in the absence of major structural disturbance: Insights from the crystal structures of filamin B actin binding domains. | Sawyer, GM., et al. 2009. J Mol Biol. 390: 1030-47. PMID: 19505475
- Filamin B regulates chondrocyte proliferation and differentiation through Cdk1 signaling. | Hu, J., et al. 2014. PLoS One. 9: e89352. PMID: 24551245
- Differential expression of filamin B splice variants in giant cell tumor cells. | Tsui, JC., et al. 2016. Oncol Rep. 36: 3181-3187. PMID: 27779699
- Filamin B Loss-of-Function Mutation in Dimerization Domain Causes Autosomal-Recessive Spondylocarpotarsal Synostosis Syndrome with Rib Anomalies. | Yang, CF., et al. 2017. Hum Mutat. 38: 540-547. PMID: 28145000
- Mechanisms and Effects on HBV Replication of the Interaction between HBV Core Protein and Cellular Filamin B. | Li, Y., et al. 2018. Virol Sin. 33: 162-172. PMID: 29594956
- Filamin B extensively regulates transcription and alternative splicing, and is associated with apoptosis in HeLa cells. | Ma, HR., et al. 2020. Oncol Rep. 43: 1536-1546. PMID: 32323860
- Filamin B knockdown impairs differentiation and function in mouse pre-osteoblasts via aberrant transcription and alternative splicing. | Wang, X., et al. 2024. Heliyon. 10: e39334. PMID: 39498024
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Filamin 3 Antibody (A-4) | sc-271698 | 200 µg/ml | $322.00 | |||
Filamin 3 Antibody (A-4): m-IgG Fc BP-HRP Bundle | sc-537683 | 200 µg Ab; 10 µg BP | $361.00 | |||
Filamin 3 Antibody (A-4): m-IgGκ BP-HRP Bundle | sc-535027 | 200 µg Ab; 40 µg BP | $361.00 | |||
Filamin 3 Antibody (A-4): m-IgG2a BP-HRP Bundle | sc-548085 | 200 µg Ab; 10 µg BP | $361.00 |