Fibulin-1 Antibody (B-2): sc-374539
- Fibulin-1 Antibody (B-2) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 83-117 within an internal region of Fibulin-1 of human origin
- recommended for detection of all Fibulin-1 isoforms of mouse, rat and human origin by WB, IP, IF and ELISA
- See Fibulin-1 (B-5): sc-25281 for Fibulin-1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Fibulin-1 Antibody (B-2) for WB applications. These reagents are now offered in bundles with Fibulin-1 Antibody (B-2) (see ordering information below).
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Fibulin-1 Antibody (B-2) is a mouse monoclonal IgG1 antibody that detects Fibulin-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Fibulin-1 is a modular glycoprotein that plays a crucial role in the formation and maintenance of the elastic extracellular matrix, basement membranes, and blood vessels. Fibulin-1′s ability to self-associate and bind to various proteins, including calcium, fibronectin, laminin, nidogen, and fibrinogen, highlights its importance in tissue architecture and integrity. These interactions are vital for the structural stability of connective tissues and the regulation of cellular processes, such as cell adhesion and migration. Notably, Fibulin-1 expression is influenced by estrogen in ovarian cancer cell lines, suggesting a dual role as a potential metastasis agent and a biomarker for assessing cancer risk and aggressiveness in ovarian carcinomas. Furthermore, research indicates that increased levels of Fibulin-1 can inhibit cancer cell motility, underscoring its significance in cancer biology. The precise cellular function of Fibulin-1 remains an area of active investigation, making anti-Fibulin-1 antibody (B-2) an essential tool for researchers studying its diverse roles in health and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fibulin-1 Antibody (B-2) | sc-374539 | 200 µg/ml | $316.00 | |||
Fibulin-1 Antibody (B-2): m-IgG Fc BP-HRP Bundle | sc-540469 | 200 µg Ab; 10 µg BP | $354.00 | |||
Fibulin-1 Antibody (B-2): m-IgG1 BP-HRP Bundle | sc-542143 | 200 µg Ab; 20 µg BP | $354.00 | |||
Fibulin-1 (B-2) Neutralizing Peptide | sc-374539 P | 100 µg/0.5 ml | $68.00 |