FHL-2 Antibody (A-6): sc-374062

FHL-2 Antibody (A-6) is a mouse monoclonal IgG1 antibody that detects FHL-2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FHL-2, a member of the four-and-a-half-LIM domain protein family, plays a crucial role in muscle development and function, particularly in cardiac and skeletal muscle tissues, as well as in the placenta and ovaries. FHL-2 localization in the cytosol of myoblasts, myotubes, and differentiated myocytes suggests direct involvement in regulating gene expression and cellular signaling pathways essential for muscle differentiation and function. Notably, FHL-2 interacts with various transcription factors, including CREB and CREM, which are vital for mediating cellular responses to hormonal and environmental signals. FHL-2′s ability to selectively activate these transcription factors underscores its importance in muscle physiology and development, making FHL-2 a valuable target for research in muscle-related diseases and conditions. Anti-FHL-2 antibody (A-6) serves as an essential tool for researchers exploring the intricate roles of FHL proteins in various biological processes.

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FHL-2 Antibody (A-6) References:

1. The biological relevance of FHL2 in tumour cells and its role as a putative cancer target.  |  Kleiber, K., et al. 2007. Anticancer Res. 27: 55-61. PMID: 17352216
2. FHL-2 suppresses VEGF-induced phosphatidylinositol 3-kinase/Akt activation via interaction with sphingosine kinase-1.  |  Hayashi, H., et al. 2009. Arterioscler Thromb Vasc Biol. 29: 909-14. PMID: 19325137
3. Deletion of FHL2 gene impaired ischemia-induced blood flow recovery by modulating circulating proangiogenic cells.  |  Huang, PH., et al. 2013. Arterioscler Thromb Vasc Biol. 33: 709-17. PMID: 23413425
4. Protein-protein interactions of the LIM-only protein FHL2 and functional implication of the interactions relevant in cardiovascular disease.  |  Tran, MK., et al. 2016. Biochim Biophys Acta. 1863: 219-28. PMID: 26548523
5. The LIM-Only Protein FHL2 is involved in Autophagy to Regulate the Development of Skeletal Muscle Cell.  |  Liu, Z., et al. 2019. Int J Biol Sci. 15: 838-846. PMID: 30906214
6. Four-and-a-half LIM domain protein 2 (FHL2) deficiency protects mice from diet-induced obesity and high FHL2 expression marks human obesity.  |  Clemente-Olivo, MP., et al. 2021. Metabolism. 121: 154815. PMID: 34119536
7. High FHL2 mRNA expression and its prognostic value in lung cancer.  |  Jiao, Y., et al. 2022. Aging (Albany NY). 14: 7986-8000. PMID: 36227138
8. FHL2 regulates microglia M1/M2 polarization after spinal cord injury via PARP14-depended STAT1/6 pathway.  |  Xu, A., et al. 2023. Int Immunopharmacol. 124: 110853. PMID: 37708708
9. Four and a half LIM domains 2 (FHL2) attenuates tumorigenesis of gastrointestinal stromal tumors (GISTs) by negatively regulating KIT signaling.  |  Zhang, S., et al. 2024. Mol Carcinog. 63: 1334-1348. PMID: 38629424
10. The roles of FHL2 as a mechanotransducer for cellular functions in the mechanical environment.  |  Fujimoto, Y. and Nakazawa, N. 2024. Front Cell Dev Biol. 12: 1431690. PMID: 39129787

The preferred FHL-2 antibody is FHL-2 Antibody (F-1): sc-393514.