Fhit Antibody (C-7): sc-271621
- Fhit Antibody (C-7) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 111-147 near the C-terminus of Fhit of human origin
- recommended for detection of Fhit of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG1 BP-HRP is the preferred secondary detection reagent for Fhit Antibody (C-7) for WB applications. This reagent is now offered in a bundle with Fhit Antibody (C-7) (see ordering information below).
QUICK LINKS
SEE ALSO...
Fhit Antibody (C-7) is a mouse monoclonal IgG1 antibody that detects Fhit in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Fhit is a crucial protein that plays a significant role in cellular processes, particularly in the regulation of apoptosis and DNA repair, which are vital for maintaining genomic stability and preventing tumorigenesis. Fhit protein is a member of the histidine triad (HIT) superfamily and functions as a dinucleoside 5′,5′′′-P1,P3-triphosphate hydrolase, which is essential for hydrolyzing dinucleoside polyphosphates, thereby influencing nucleotide metabolism and signaling pathways. The importance of Fhit in cancer biology is underscored by its association with various malignancies, where alterations in expression and function can lead to increased susceptibility to carcinogenic factors. Anti-Fhit antibody (C-7) provides a reliable tool for researchers investigating the role of Fhit in cancer and other diseases, facilitating a deeper understanding of its function and potential as a therapeutic target.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Fhit Antibody (C-7) References:
- FHIT: from gene discovery to cancer treatment and prevention. | Pekarsky, Y., et al. 2002. Lancet Oncol. 3: 748-54. PMID: 12473516
- Fhit expression protects against HER2-driven breast tumor development: unraveling the molecular interconnections. | Bianchi, F., et al. 2007. Cell Cycle. 6: 643-6. PMID: 17374991
- Small-Molecule Inhibitors of the Tumor Suppressor Fhit. | Lange, S., et al. 2017. Chembiochem. 18: 1707-1711. PMID: 28643453
- Impact of FHIT loss on the translation of cancer-associated mRNAs. | Kiss, DL., et al. 2017. Mol Cancer. 16: 179. PMID: 29282095
- Mechanisms shaping the mutational landscape of the FRA3B/FHIT-deficient cancer genome. | Saldivar, JC. and Park, D. 2019. Genes Chromosomes Cancer. 58: 317-323. PMID: 30242938
- Fhit induces the reciprocal suppressions between Lin28/Let-7 and miR-17/92miR. | Chae, HJ., et al. 2021. Int J Med Sci. 18: 706-714. PMID: 33437205
- FHIT as a biomarker for early screening of adult T-cell leukemia. | Bellon, M. and Nicot, C. 2021. J Cancer Biol. 2: 71-74. PMID: 35663592
- Expression of Tumor Suppressor FHIT Is Regulated by the LINC00173-SNAIL Axis in Human Lung Adenocarcinoma. | Suzuki, T., et al. 2023. Int J Mol Sci. 24: PMID: 38069335
- Integrated analysis of FHIT gene alterations in cancer. | Simón-Carrasco, L., et al. 2024. Cell Cycle. 23: 92-113. PMID: 38234243
- Arabidopsis Fhit-like tumor suppressor resumes early terminated constitutive triple response1-10 mRNA translation. | Zhang, R., et al. 2024. Plant Physiol. 195: 2073-2093. PMID: 38563472
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fhit Antibody (C-7) | sc-271621 | 200 µg/ml | $322.00 | |||
Fhit Antibody (C-7): m-IgG1 BP-HRP Bundle | sc-542680 | 200 µg Ab; 20 µg BP | $361.00 | |||
Fhit (C-7) Neutralizing Peptide | sc-271621 P | 100 µg/0.5 ml | $69.00 |