FGFR-4 Antibody (A-10): sc-136988

FGFR-4 Antibody (A-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects FGFR-4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). FGFR-4 (A-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FGFR-4, also known as fibroblast growth factor receptor 4 or CD334, plays a crucial role in cellular signaling pathways that regulate cell proliferation, differentiation, and survival, particularly in mesenchymal and epithelial tissues. FGFR-4 function is vital for normal development and tissue homeostasis, and dysregulation of FGFR-4 has been implicated in various cancers and developmental disorders. Additionally, FGFR-4 interacts with specific fibroblast growth factors, which are essential for mediating biological effects, making FGFR-4 important for understanding both normal physiology and disease mechanisms.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

FGFR-4 Antibody (A-10) References:

1. Expression and glycosylation studies of human FGF receptor 4.  |  Tuominen, H., et al. 2001. Protein Expr Purif. 21: 275-85. PMID: 11237689
2. Characterization of the murine BEK fibroblast growth factor (FGF) receptor: activation by three members of the FGF family and requirement for heparin.  |  Mansukhani, A., et al. 1992. Proc Natl Acad Sci U S A. 89: 3305-9. PMID: 1373495
3. Localization of the fibroblast growth factor receptor-4 gene to chromosome region 5q33-qter.  |  Armstrong, E., et al. 1992. Genes Chromosomes Cancer. 4: 94-8. PMID: 1377018
4. Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.  |  Dionne, CA., et al. 1990. EMBO J. 9: 2685-92. PMID: 1697263
5. FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern.  |  Partanen, J., et al. 1991. EMBO J. 10: 1347-54. PMID: 1709094
6. Recent developments in the cell biology of basic fibroblast growth factor.  |  Rifkin, DB. and Moscatelli, D. 1989. J Cell Biol. 109: 1-6. PMID: 2545723
7. Overexpression of Fli-1 is associated with adverse prognosis of endometrial cancer.  |  Song, W., et al. 2015. Cancer Invest. 33: 469-75. PMID: 26305602
8. The role of FLI-1-EWS, a fusion gene reciprocal to EWS-FLI-1, in Ewing sarcoma.  |  Elzi, DJ., et al. 2015. Genes Cancer. 6: 452-61. PMID: 26807198
9. Transcription factor Fli-1 positively regulates lipopolysaccharide-induced interleukin-27 production in macrophages.  |  Gao, P., et al. 2016. Mol Immunol. 71: 184-191. PMID: 26900987
10. Fli‑1 promotes metastasis by regulating MMP2 signaling in hepatocellular carcinoma.  |  Wang, H., et al. 2018. Mol Med Rep. 17: 1986-1992. PMID: 29138848
11. Expression of Friend Leukemia Integration-1 (Fli-1) and the Apoptosis Regulator B Cell Lymphoma-2 (BCL-2) in Gastric Carcinoma; an Immunohistochemical Study.  |  Hemida, AS. and Holah, NS. 2022. J Immunoassay Immunochem. 43: 1954948. PMID: 34314292
12. Mr 25,000 heparin-binding protein from guinea pig brain is a high molecular weight form of basic fibroblast growth factor.  |  Moscatelli, D., et al. 1987. Proc Natl Acad Sci U S A. 84: 5778-82. PMID: 3475702

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FGFR-4 Antibody (A-10) has 32 citations in a variety of scientific publications.

Primary antibodies like Anti-FGFR-4 Antibody (A-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FGFR-4 Antibody (A-10) Specifications

Alternate Product Name: FGFR4

Product Clone Name: A-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 25-145

Epitope Target: FGFR-4

Epitope Species: human

Product Reactivity/Detection: FGFR-4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 32 citations in various scientific publications

Available Conjugates/Forms for FGFR-4 Antibody (A-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin