FGFR-3 Antibody (B-9): sc-13121

FGFR-3 Antibody (B-9) is a mouse monoclonal IgG2a kappa light chain antibody that detects FGFR-3 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). FGFR-3 monoclonal antibody (B-9) is available in both conjugated and non-conjugated forms, providing versatility for various experimental needs. FGFR-3, a member of the fibroblast growth factor receptor family, plays a crucial role in regulating cell growth, differentiation, and tissue repair. FGFR-3 is primarily located on the cell surface, where FGFR-3 binds to fibroblast growth factors, initiating a cascade of intracellular signaling that influences cellular processes such as proliferation and survival. Proper functioning of FGFR-3 is vital for normal skeletal development, and mutations in FGFR-3 can lead to a range of skeletal dysplasias, including achondroplasia and thanatophoric dysplasia, highlighting FGFR-3′s importance in human health. Additionally, aberrations in FGFR-3 signaling have been implicated in certain cancers, making FGFR-3 a significant target for therapeutic intervention. The gene encoding FGFR-3 is located on chromosome 4p16 and produces multiple isoforms through alternative splicing, which are expressed in various tissues, including the brain, kidney, and testis. Understanding the role of FGFR-3 in both normal physiology and disease states underscores the relevance of FGFR-3 antibody (B-9) in research and clinical applications.

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FGFR-3 Antibody (B-9) References:

1. Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas.  |  Cappellen, D., et al. 1999. Nat Genet. 23: 18-20. PMID: 10471491
2. Clinical characteristics of patients with unicoronal synostosis and mutations of fibroblast growth factor receptor 3: a preliminary report.  |  Cassileth, LB., et al. 2001. Plast Reconstr Surg. 108: 1849-54. PMID: 11743367
3. Characterization of the murine BEK fibroblast growth factor (FGF) receptor: activation by three members of the FGF family and requirement for heparin.  |  Mansukhani, A., et al. 1992. Proc Natl Acad Sci U S A. 89: 3305-9. PMID: 1373495
4. Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.  |  Dionne, CA., et al. 1990. EMBO J. 9: 2685-92. PMID: 1697263
5. Fibroblast growth factor receptor-3 (FGFR-3) regulates expression of paneth cell lineage-specific genes in intestinal epithelial cells through both TCF4/beta-catenin-dependent and -independent signaling pathways.  |  Brodrick, B., et al. 2011. J Biol Chem. 286: 18515-25. PMID: 21388956
6. Recent developments in the cell biology of basic fibroblast growth factor.  |  Rifkin, DB. and Moscatelli, D. 1989. J Cell Biol. 109: 1-6. PMID: 2545723
7. Fibroblast Growth Factor (FGF-2) and Its Receptors FGFR-2 and FGFR-3 May Be Putative Biomarkers of Malignant Transformation of Potentially Malignant Oral Lesions into Oral Squamous Cell Carcinoma.  |  Nayak, S., et al. 2015. PLoS One. 10: e0138801. PMID: 26465941
8. Mr 25,000 heparin-binding protein from guinea pig brain is a high molecular weight form of basic fibroblast growth factor.  |  Moscatelli, D., et al. 1987. Proc Natl Acad Sci U S A. 84: 5778-82. PMID: 3475702
9. Fibroblast growth factor receptor 3 (FGFR3) transmembrane mutation in Crouzon syndrome with acanthosis nigricans.  |  Meyers, GA., et al. 1995. Nat Genet. 11: 462-4. PMID: 7493034
10. The choice between alternative IIIb and IIIc exons of the FGFR-3 gene is not strictly tissue-specific.  |  Scotet, E. and Houssaint, E. 1995. Biochim Biophys Acta. 1264: 238-42. PMID: 7495869
11. A glycine 375-to-cysteine substitution in the transmembrane domain of the fibroblast growth factor receptor-3 in a newborn with achondroplasia.  |  Superti-Furga, A., et al. 1995. Eur J Pediatr. 154: 215-9. PMID: 7758520
12. Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3.  |  Tavormina, PL., et al. 1995. Nat Genet. 9: 321-8. PMID: 7773297

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FGFR-3 Antibody (B-9) has 133 citations in a variety of scientific publications.

Primary antibodies like Anti-FGFR-3 Antibody (B-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FGFR-3 Antibody (B-9) Specifications

Alternate Product Name: FGFR3

Product Clone Name: B-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 25-124

Epitope Target: FGFR-3

Epitope Species: human

Product Reactivity/Detection: FGFR-3

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 133 citations in various scientific publications

Available Conjugates/Forms for FGFR-3 Antibody (B-9): AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790

The preferred FGFR-3 antibody is FGFR-3 Antibody (E-7): sc-390423.