ferritin light chain Antibody (D-1): sc-390558

Ferritin light chain Antibody (D-1) is a mouse monoclonal IgG1 antibody that detects ferritin light chain in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Ferritin light chain plays a crucial role in iron metabolism and cellular protection against oxidative stress, making ferritin light chain essential for maintaining cellular homeostasis. Ferritin light chain is primarily located in the cytoplasm and is involved in the storage and release of iron, which is vital for various cellular processes, including DNA synthesis and cellular respiration. The ability of ferritin light chain to sequester excess iron helps prevent the formation of harmful free radicals, thereby protecting cells from oxidative damage. Additionally, alterations in ferritin light chain expression have been linked to pathological conditions such as hereditary hyperferritinemia cataract syndrome, where ferritin light chain overexpression contributes to cataract formation. The gene encoding ferritin light chain is located on chromosome 19q13.3-q13.4, and understanding ferritin light chain function and regulation is critical for elucidating ferritin light chain′s role in both normal physiology and disease states. Anti-ferritin light chain antibody (D-1) is an invaluable tool for researchers investigating iron metabolism and related disorders.

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ferritin light chain Antibody (D-1) References:

1. Repression of ferritin light chain translation by human eIF3.  |  Pulos-Holmes, MC., et al. 2019. Elife. 8: PMID: 31414986
2. Transcriptional Repression of Ferritin Light Chain Increases Ferroptosis Sensitivity in Lung Adenocarcinoma.  |  Wang, Y., et al. 2021. Front Cell Dev Biol. 9: 719187. PMID: 34765600
3. JNK/Itch Axis Mediates the Lipopolysaccharide-Induced Ubiquitin-Proteasome-Dependent Degradation of Ferritin Light Chain in Murine Macrophage Cells.  |  He, S., et al. 2022. Inflammation. 45: 1089-1100. PMID: 34837126
4. Ciliated (FOXJ1+) Cells Display Reduced Ferritin Light Chain in the Airways of Idiopathic Pulmonary Fibrosis Patients.  |  Wijk, SC., et al. 2022. Cells. 11: PMID: 35326483
5. Autoantibody Against Ferritin Light Chain is a Serum Biomarker for the Detection of Liver Cirrhosis but Not Liver Cancer.  |  Ren, P., et al. 2022. J Hepatocell Carcinoma. 9: 221-232. PMID: 35378780
6. SCARA5 induced ferroptosis to effect ESCC proliferation and metastasis by combining with Ferritin light chain.  |  Liu, Y., et al. 2022. BMC Cancer. 22: 1304. PMID: 36513999
7. Myeloid-specific ferritin light chain deletion does not exacerbate sepsis-associated AKI.  |  Odum, JD., et al. 2024. Am J Physiol Renal Physiol. 327: F171-F183. PMID: 38779751
8. Ferritin Light Chain Alleviates Cerebral Ischemic-Reperfusion Injury-Induced Neuroinflammation via the HIF1α Mediated NF-κB Signaling Pathways.  |  Jiang, H., et al. 2024. Inflammation.. PMID: 39066965
9. Lipocalin-2 inhibition alleviates neural injury by microglia ferroptosis suppression after experimental intracerebral hemorrhage in mice via enhancing ferritin light chain expression.  |  Fei, X., et al. 2024. Biochim Biophys Acta Mol Basis Dis. 1870: 167435. PMID: 39067535
10. Ferritin light chain as a potential biomarker for the prognosis of liver hepatocellular carcinoma.  |  Li, A., et al. 2024. Heliyon. 10: e36040. PMID: 39224384

The preferred ferritin light chain antibody is ferritin light chain Antibody (D-9): sc-74513.