FcRn Antibody (H-4): sc-166413
- FcRn Antibody (H-4) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 22-276 mapping within an N-terminal extracellular domain of FcRn of mouse origin
- recommended for detection of FcRn of mouse, rat and human origin by WB, IP, IF and ELISA
- See FcRn (B-8): sc-271745 for FcRn antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for FcRn Antibody (H-4) for WB applications. These reagents are now offered in bundles with FcRn Antibody (H-4) (see ordering information below).
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FcRn Antibody (H-4) is a mouse monoclonal IgG1 antibody that detects FcRn in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FcRn, also known as FCGRT, Brambell receptor, FcRn α chain, and IgG Gc receptor, plays a crucial role in the immune system by mediating the selective uptake of immunoglobulin G (IgG) from maternal milk in neonatal mice and rats, thereby facilitating the acquisition of passive immunity in newborns. FcRn is primarily located in the endosomes of vascular endothelial cells, where FcRn selectively recycles IgG back to the cell surface, protecting IgG from lysosomal degradation. This recycling mechanism is vital for maintaining the longevity of IgG, which are the most enduring plasma proteins, ensuring that newborns receive essential antibodies for immune defense during early development. FcRn Antibody (H-4) serves as an invaluable tool for researchers studying immune responses, antibody recycling, and the mechanisms of passive immunity, providing insights into both basic biology and potential therapeutic applications.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FcRn Antibody (H-4) | sc-166413 | 200 µg/ml | $322.00 | |||
FcRn Antibody (H-4): m-IgG Fc BP-HRP Bundle | sc-540098 | 200 µg Ab; 10 µg BP | $361.00 | |||
FcRn Antibody (H-4): m-IgG1 BP-HRP Bundle | sc-541902 | 200 µg Ab; 20 µg BP | $361.00 |