FBXO2 Antibody (E-9): sc-398111

FBXO2 Antibody (E-9) is a mouse monoclonal IgG1 antibody that detects FBXO2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FBXO2, also known as F-box protein 2, FBX2, FBG1, or NFB42, is a 296 amino acid protein that plays a pivotal role in the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex, which is essential for substrate recognition and recruitment for ubiquitination. FBXO2 contains one F-box domain and one F-box associated domain, allowing selective binding to phosphorylated substrates, thereby facilitating ubiquitination and subsequent proteasomal degradation. FBXO2′s ability to target specific proteins, such as cyclins and cyclin-dependent kinase inhibitors, is crucial for regulating various cellular processes, including the cell cycle and immune responses. By modulating the degradation of key regulatory proteins, FBXO2 helps maintain cellular homeostasis and influences critical signaling pathways, making FBXO2 an important player in developmental events and cellular signaling cascades. Anti-FBXO2 antibody (E-9) is an invaluable tool for researchers studying the intricate mechanisms of protein regulation and degradation in human cells.

The preferred FBXO2 antibody is FBXO2 Antibody (A-12): sc-393873.