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FBXO2 Antibody (A-12): sc-393873

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Datasheets
  • FBXO2 Antibody (A-12) is a mouse monoclonal IgM κ FBXO2 antibody, cited in 5 publications, provided at 200 µg/ml
  • specific for an epitope mapping between amino acids 140-171 within an internal region of FBXO2 of human origin
  • recommended for detection of FBXO2 of mouse, rat and human origin by WB, IP, IF and ELISA
  • At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for FBXO2 Antibody (A-12). This work is in progress.

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FBXO2 Antibody (A-12) is a mouse monoclonal IgM antibody that detects FBXO2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-FBXO2 antibody (A-12) is available as a non-conjugated monoclonal isotype antibody. FBXO2, also known as F-box protein 2, FBX2, FBG1, or NFB42, is a 296 amino acid protein that plays a pivotal role in the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex, which is essential for substrate recognition and recruitment for ubiquitination. FBXO2 contains one F-box domain and one F-box associated domain, allowing selective binding to phosphorylated substrates, thereby facilitating ubiquitination and subsequent proteasomal degradation. FBXO2 regulates various cellular processes, including cell cycle, immune responses, and signaling pathways, by targeting key proteins such as cyclins and IκB-α for degradation. Through modulation of these proteins, FBXO2 maintains cellular homeostasis and ensures proper cellular function, making FBXO2 a significant player in both normal physiology and disease states.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

FBXO2 Antibody (A-12) References:

  1. Identification of a family of human F-box proteins.  |  Cenciarelli, C., et al. 1999. Curr Biol. 9: 1177-9. PMID: 10531035
  2. A family of mammalian F-box proteins.  |  Winston, JT., et al. 1999. Curr Biol. 9: 1180-2. PMID: 10531037
  3. E3 ubiquitin ligase that recognizes sugar chains.  |  Yoshida, Y., et al. 2002. Nature. 418: 438-42. PMID: 12140560
  4. A new subfamily of structurally related human F-box proteins.  |  Ilyin, GP., et al. 2002. Gene. 296: 11-20. PMID: 12383498
  5. Replication-initiator protein (UL9) of the herpes simplex virus 1 binds NFB42 and is degraded via the ubiquitin-proteasome pathway.  |  Eom, CY. and Lehman, IR. 2003. Proc Natl Acad Sci U S A. 100: 9803-7. PMID: 12904574
  6. A novel F box protein, NFB42, is highly enriched in neurons and induces growth arrest.  |  Erhardt, JA., et al. 1998. J Biol Chem. 273: 35222-7. PMID: 9857061

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

FBXO2 Antibody (A-12)

sc-393873
200 µg/ml
$316.00

FBXO2 (A-12) Neutralizing Peptide

sc-393873 P
100 µg/0.5 ml
$68.00

What application is the blocking peptide sc-393873 P appropriate for?

Asked by: Trav11
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Produced positive Western blot data of FBXO2Produced positive Western blot data of FBXO2 expression in non-transfected 293T, mouse FBXO2 transfected 293T and Hep G2 whole cell lysates. -SCBT QC
Date published: 2014-12-04
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FBXO2 Antibody (A-12) is rated 5.0 out of 5 by 1.
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