FBXO2 Antibody (A-12): sc-393873

FBXO2 Antibody (A-12) is a mouse monoclonal IgM antibody that detects FBXO2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-FBXO2 antibody (A-12) is available as a non-conjugated monoclonal isotype antibody. FBXO2, also known as F-box protein 2, FBX2, FBG1, or NFB42, is a 296 amino acid protein that plays a pivotal role in the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex, which is essential for substrate recognition and recruitment for ubiquitination. FBXO2 contains one F-box domain and one F-box associated domain, allowing selective binding to phosphorylated substrates, thereby facilitating ubiquitination and subsequent proteasomal degradation. FBXO2 regulates various cellular processes, including cell cycle, immune responses, and signaling pathways, by targeting key proteins such as cyclins and IκB-α for degradation. Through modulation of these proteins, FBXO2 maintains cellular homeostasis and ensures proper cellular function, making FBXO2 a significant player in both normal physiology and disease states.

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FBXO2 Antibody (A-12) References:

1. Identification of a family of human F-box proteins.  |  Cenciarelli, C., et al. 1999. Curr Biol. 9: 1177-9. PMID: 10531035
2. A family of mammalian F-box proteins.  |  Winston, JT., et al. 1999. Curr Biol. 9: 1180-2. PMID: 10531037
3. E3 ubiquitin ligase that recognizes sugar chains.  |  Yoshida, Y., et al. 2002. Nature. 418: 438-42. PMID: 12140560
4. A new subfamily of structurally related human F-box proteins.  |  Ilyin, GP., et al. 2002. Gene. 296: 11-20. PMID: 12383498
5. Replication-initiator protein (UL9) of the herpes simplex virus 1 binds NFB42 and is degraded via the ubiquitin-proteasome pathway.  |  Eom, CY. and Lehman, IR. 2003. Proc Natl Acad Sci U S A. 100: 9803-7. PMID: 12904574
6. A novel F box protein, NFB42, is highly enriched in neurons and induces growth arrest.  |  Erhardt, JA., et al. 1998. J Biol Chem. 273: 35222-7. PMID: 9857061

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FBXO2 Antibody (A-12) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-FBXO2 Antibody (A-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FBXO2 Antibody (A-12) Specifications

Alternate Product Name: FBXO2

Product Clone Name: A-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 140-171

Epitope Target: FBXO2

Epitope Species: human

Product Reactivity/Detection: FBXO2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for FBXO2 Antibody (A-12): P: Blocking Peptide