FBP1 Antibody (A-4): sc-393928

FBP1 Antibody (A-4) is a mouse monoclonal IgG1 antibody that detects FBP1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FUSE-binding protein 1 (FBP1) plays a crucial role in regulating the expression of the c-Myc gene, which is essential for cell proliferation and growth. FBP1 is primarily located in the nucleus, where FBP1 binds to the far upstream element (FUSE) of the c-Myc gene, facilitating transcription in undifferentiated cells. This nuclear localization enables FBP1 to act as a growth-dependent regulator, ensuring that c-Myc expression is tightly controlled during cellular growth and differentiation. FBP1 expression significantly reduces following cellular differentiation, highlighting FBP1′s importance in maintaining the proliferative state of cells. The FBP family, including FBP1, FBP2, and FBP3, consists of single-stranded DNA-binding proteins that share a conserved central DNA-binding domain, underscoring their functional similarities in gene regulation. Anti-FBP1 antibody (A-4) serves as an invaluable tool for researchers studying the mechanisms of cell growth and differentiation, as well as the intricate regulatory networks involving c-Myc.

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FBP1 Antibody (A-4) References:

1. Dysfunction of Natural Killer Cells by FBP1-Induced Inhibition of Glycolysis during Lung Cancer Progression.  |  Cong, J., et al. 2018. Cell Metab. 28: 243-255.e5. PMID: 30033198
2. FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome.  |  Li, F., et al. 2020. Nat Cell Biol. 22: 728-739. PMID: 32367049
3. FBP1-Altered Carbohydrate Metabolism Reduces Leukemic Viability through Activating P53 and Modulating the Mitochondrial Quality Control System In Vitro.  |  Xu, Y., et al. 2022. Int J Mol Sci. 23: PMID: 36232688
4. Hepatic but not Intestinal FBP1 Is Required for Fructose Metabolism and Tolerance.  |  Bai, Q., et al. 2023. Endocrinology. 164: PMID: 36964915
5. AF9 sustains glycolysis in colorectal cancer via H3K9ac-mediated PCK2 and FBP1 transcription.  |  He, X., et al. 2023. Clin Transl Med. 13: e1352. PMID: 37565737
6. Fructose-bisphosphatase1 (FBP1) alleviates experimental osteoarthritis by regulating Protein crumbs homolog 3 (CRB3).  |  Wang, Z., et al. 2023. Arthritis Res Ther. 25: 235. PMID: 38049890
7. The translational potential of miR-26 in atherosclerosis and development of agents for its target genes ACC1/2, COL1A1, CPT1A, FBP1, DGAT2, and SMAD7.  |  Chen, W., et al. 2024. Cardiovasc Diabetol. 23: 21. PMID: 38195542
8. Hypoxia-induced P4HA1 overexpression promotes post-ischemic angiogenesis by enhancing endothelial glycolysis through downregulating FBP1.  |  Xu, Y., et al. 2024. J Transl Med. 22: 74. PMID: 38238754
9. FBP1 inhibits NSCLC stemness by promoting ubiquitination of Notch1 intracellular domain and accelerating degradation.  |  He, T., et al. 2024. Cell Mol Life Sci. 81: 87. PMID: 38349431
10. FBP1 orchestrates keratinocyte proliferation/differentiation and suppresses psoriasis through metabolic control of histone acetylation.  |  Zhang, P., et al. 2024. Cell Death Dis. 15: 392. PMID: 38834617

The preferred FBP1 antibody is FBP1 Antibody (G-8): sc-271241.