Fascin 1 Antibody (D-10): sc-46675
- Fascin 1 Antibody (D-10) is a mouse monoclonal IgG1 κ Fascin 1 antibody, cited in 24 publications, provided at 200 µg/ml
- raised against amino acids 384-493 of Fascin 1 of human origin
- Fascin 1 Antibody (D-10) is recommended for detection of Fascin 1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-Fascin 1 Antibody (D-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Fascin 1 Antibody (D-10) for WB and IHC(P) applications. These reagents are now offered in bundles with Fascin 1 Antibody (D-10) (see ordering information below).
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Fascin 1 Antibody (D-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects Fascin 1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Fascin 1 (D-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Fascin 1 plays a crucial role in organizing the actin cytoskeleton, particularly in forming actin microspikes, which are essential for cell adhesion and migration. These microspikes form in response to extracellular matrix components, such as thrombospondin 1, and are vital for processes like tissue remodeling and wound healing. The ability of Fascin to bundle actin filaments within dynamic cellular structures, including microspikes, stress fibers, and membrane ruffles, underscores its importance in maintaining cellular architecture and facilitating motility. Fascin 1 has been identified as a potential prognostic marker for abnormal ovarian epithelial pathology and represents a novel therapeutic target in ovarian cancer treatment. Fascin serves as a key identifier for dendritic cells in both blood and tissue, highlighting its significance in immune responses.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Fascin 1 Antibody (D-10) References:
- Fascin-1 as a novel diagnostic marker of triple-negative breast cancer. | Wang, CQ., et al. 2016. Cancer Med. 5: 1983-8. PMID: 27184764
- Studying the role of fascin-1 in mechanically stressed podocytes. | Kliewe, F., et al. 2017. Sci Rep. 7: 9916. PMID: 28855604
- Fascin-1 Contributes to Neuropathic Pain by Promoting Inflammation in Rat Spinal Cord. | Wang, B., et al. 2018. Neurochem Res. 43: 287-296. PMID: 29052088
- Fascin-1 is Highly Expressed Specifically in Microglia After Spinal Cord Injury and Regulates Microglial Migration. | Yu, S., et al. 2021. Front Pharmacol. 12: 729524. PMID: 34646136
- STAT3/HIF-1α/fascin-1 axis promotes RA FLSs migration and invasion ability under hypoxia. | Yang, W., et al. 2022. Mol Immunol. 142: 83-94. PMID: 34971867
- The actin-bundling protein Fascin-1 modulates ciliary signalling. | Brücker, L., et al. 2023. J Mol Cell Biol. 15: PMID: 37015875
- The crucial role of fascin-1 in the pathogenesis, metastasis, and chemotherapeutic resistance of breast cancer. | Abdullah, AR., et al. 2024. Pathol Res Pract. 254: 155079. PMID: 38219494
- A nanobody inhibitor of Fascin-1 actin-bundling activity and filopodia formation. | Burgess, SG., et al. 2024. Open Biol. 14: 230376. PMID: 38503329
- Expression of Fascin-1 and its diagnostic value in liver cancer. | Lu, SP., et al. 2024. Sci Rep. 14: 10049. PMID: 38698008
- Fascin-1 Promotes Cell Metastasis through Epithelial-Mesenchymal Transition in Canine Mammary Tumor Cell Lines. | Wang, X., et al. 2024. Vet Sci. 11: PMID: 38921985
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fascin 1 Antibody (D-10) | sc-46675 | 200 µg/ml | $322.00 | |||
Fascin 1 Antibody (D-10): m-IgG Fc BP-HRP Bundle | sc-526720 | 200 µg Ab; 10 µg BP | $361.00 | |||
Fascin 1 Antibody (D-10): m-IgG1 BP-HRP Bundle | sc-532093 | 200 µg Ab; 20 µg BP | $361.00 | |||
Fascin 1 Antibody (D-10) AC | sc-46675 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Fascin 1 Antibody (D-10) HRP | sc-46675 HRP | 200 µg/ml | $322.00 | |||
Fascin 1 Antibody (D-10) FITC | sc-46675 FITC | 200 µg/ml | $336.00 | |||
Fascin 1 Antibody (D-10) PE | sc-46675 PE | 200 µg/ml | $349.00 | |||
Fascin 1 Antibody (D-10) Alexa Fluor® 488 | sc-46675 AF488 | 200 µg/ml | $364.00 | |||
Fascin 1 Antibody (D-10) Alexa Fluor® 546 | sc-46675 AF546 | 200 µg/ml | $364.00 | |||
Fascin 1 Antibody (D-10) Alexa Fluor® 594 | sc-46675 AF594 | 200 µg/ml | $364.00 | |||
Fascin 1 Antibody (D-10) Alexa Fluor® 647 | sc-46675 AF647 | 200 µg/ml | $364.00 | |||
Fascin 1 Antibody (D-10) Alexa Fluor® 680 | sc-46675 AF680 | 200 µg/ml | $364.00 | |||
Fascin 1 Antibody (D-10) Alexa Fluor® 790 | sc-46675 AF790 | 200 µg/ml | $364.00 |