Fascin 1 Antibody (55K-2): sc-21743

Fascin 1 Antibody (55K-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects Fascin 1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-Fascin 1 antibody (55K-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Fascin 1 plays a crucial role in organizing the actin cytoskeleton, particularly in forming F-actin microspikes essential for cell adhesion and migration. These microspikes, formed upon adhesion to extracellular matrix glycoprotein Thrombospondin 1, are vital for cellular processes such as tissue remodeling and wound repair. By bundling actin microfilaments, Fascin 1 contributes to the structural integrity of dynamic cellular formations, including microspikes, stress fibers, and membrane ruffles. Fascin 1 has been identified as a potential prognostic factor for abnormal ovarian epithelial pathology and represents a novel therapeutic target in ovarian cancer treatment. Fascin 1′s ability to identify dendritic cells in both blood and tissues further underscores its significance in immunological responses and cellular dynamics.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Fascin 1 Antibody (55K-2) References:

1. Fascin and the differential diagnosis of childhood histiocytic lesions.  |  Jaffe, R., et al. 1998. Pediatr Dev Pathol. 1: 216-21. PMID: 10463281
2. Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes.  |  Tubb, BE., et al. 2000. Genomics. 65: 146-56. PMID: 10783262
3. Stimulation of fascin spikes by thrombospondin-1 is mediated by the GTPases Rac and Cdc42.  |  Adams, JC. and Schwartz, MA. 2000. J Cell Biol. 150: 807-22. PMID: 10953005
4. Fascin, an actin-bundling protein associated with cell motility, is upregulated in hormone receptor negative breast cancer.  |  Grothey, A., et al. 2000. Br J Cancer. 83: 870-3. PMID: 10970687
5. Increased expression of fascin, motility associated protein, in cell cultures derived from ovarian cancer and in borderline and carcinomatous ovarian tumors.  |  Hu, W., et al. 2000. Clin Exp Metastasis. 18: 83-8. PMID: 11206843
6. The Actin Bundling Protein Fascin-1 as an ACE2-Accessory Protein.  |  Ogunlade, B., et al. 2022. Cell Mol Neurobiol. 42: 255-263. PMID: 32865675
7. Emerging Role of Fascin-1 in the Pathogenesis, Diagnosis, and Treatment of the Gastrointestinal Cancers.  |  Ristic, B., et al. 2021. Cancers (Basel). 13: PMID: 34064154
8. Fascin-1 is associated with recurrence in solitary fibrous tumor/hemangiopericytoma.  |  Yamamoto, Y., et al. 2021. Mol Clin Oncol. 15: 199. PMID: 34462655
9. The role of fascin-1 in the pathogenesis, diagnosis and management of respiratory related cancers.  |  Zhang, N., et al. 2022. Front Oncol. 12: 948110. PMID: 36033434
10. Fascin-1: Updated biological functions and therapeutic implications in cancer biology.  |  Li, CH., et al. 2022. BBA Adv. 2: 100052. PMID: 37082587
11. Fascin-1 expression is associated with neuroendocrine prostate cancer and directly suppressed by androgen receptor.  |  Turpin, A., et al. 2023. Br J Cancer. 129: 1903-1914. PMID: 37875732
12. Fascin-1 limits myosin activity in microglia to control mechanical characterization of the injured spinal cord.  |  Huang, J., et al. 2024. J Neuroinflammation. 21: 88. PMID: 38600569

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Fascin 1 Antibody (55K-2) has 60 citations in a variety of scientific publications.

Primary antibodies like Anti-Fascin 1 Antibody (55K-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Fascin 1 Antibody (55K-2) Specifications

Alternate Product Name: Fascin 1

Product Clone Name: 55K-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Fascin

Epitope Species: human

Product Reactivity/Detection: Fascin 1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 60 citations in various scientific publications

Available Conjugates/Forms for Fascin 1 Antibody (55K-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin