FANCG Antibody (F-8): sc-393382
- FANCG Antibody (F-8) is a mouse monoclonal IgG1 κ FANCG antibody, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 323-622 mapping at the C-terminus of FANCG of human origin
- FANCG Antibody (F-8) is recommended for detection of FANCG of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-FANCG Antibody (F-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for FANCG Antibody (F-8) for WB applications. These reagents are now offered in bundles with FANCG Antibody (F-8) (see ordering information below).
FANCG Antibody (F-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects FANCG protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-FANCG antibody (F-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FANCG plays a crucial role in the Fanconi anemia (FA) pathway, which is essential for the repair of DNA interstrand cross-links, thereby maintaining genomic stability. Deficiencies in FANCG can lead to increased susceptibility to DNA damage, resulting in the hallmark features of Fanconi anemia, such as bone marrow failure and chromosomal instability. FANCG is primarily localized in the nucleus, where FANCG participates in DNA repair processes, and is also expressed in the cytoplasm, with high levels found in the testis and thymus. Regulation of FANCG, particularly through post-translational modifications like phosphorylation, is vital for function; for instance, phosphorylation at serine 7 has been identified as a key modification that influences FA pathway activity. FANCG monoclonal antibody (F-8) serves as an invaluable tool for researchers studying DNA repair mechanisms and the molecular underpinnings of Fanconi anemia.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
FANCG Antibody (F-8) References:
- The fanconi anemia proteins FANCA and FANCG stabilize each other and promote the nuclear accumulation of the Fanconi anemia complex. | Garcia-Higuera, I., et al. 2000. Blood. 96: 3224-30. PMID: 11050007
- The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG. | de Winter, JP., et al. 2000. Hum Mol Genet. 9: 2665-74. PMID: 11063725
- Fanconi anemia protein, FANCG, is a phosphoprotein and is upregulated with FANCA after TNF-alpha treatment. | Futaki, M., et al. 2001. Biochem Biophys Res Commun. 281: 347-51. PMID: 11181053
- A cytoplasmic serine protein kinase binds and may regulate the Fanconi anemia protein FANCA. | Yagasaki, H., et al. 2001. Blood. 98: 3650-7. PMID: 11739169
- Phosphorylation of Fanconi anemia protein, FANCA, is regulated by Akt kinase. | Otsuki, T., et al. 2002. Biochem Biophys Res Commun. 291: 628-34. PMID: 11855836
- Phosphorylation of fanconi anemia (FA) complementation group G protein, FANCG, at serine 7 is important for function of the FA pathway. | Qiao, F., et al. 2004. J Biol Chem. 279: 46035-45. PMID: 15299017
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FANCG Antibody (F-8) | sc-393382 | 200 µg/ml | $322.00 | |||
FANCG Antibody (F-8): m-IgG Fc BP-HRP Bundle | sc-530438 | 200 µg Ab; 10 µg BP | $361.00 | |||
FANCG Antibody (F-8): m-IgGκ BP-HRP Bundle | sc-523922 | 200 µg Ab, 40 µg BP | $361.00 | |||
FANCG Antibody (F-8) AC | sc-393382 AC | 500 µg/ml, 25% agarose | $424.00 | |||
FANCG Antibody (F-8) HRP | sc-393382 HRP | 200 µg/ml | $322.00 | |||
FANCG Antibody (F-8) FITC | sc-393382 FITC | 200 µg/ml | $336.00 | |||
FANCG Antibody (F-8) PE | sc-393382 PE | 200 µg/ml | $349.00 | |||
FANCG Antibody (F-8) Alexa Fluor® 488 | sc-393382 AF488 | 200 µg/ml | $364.00 | |||
FANCG Antibody (F-8) Alexa Fluor® 546 | sc-393382 AF546 | 200 µg/ml | $364.00 | |||
FANCG Antibody (F-8) Alexa Fluor® 594 | sc-393382 AF594 | 200 µg/ml | $364.00 | |||
FANCG Antibody (F-8) Alexa Fluor® 647 | sc-393382 AF647 | 200 µg/ml | $364.00 | |||
FANCG Antibody (F-8) Alexa Fluor® 680 | sc-393382 AF680 | 200 µg/ml | $364.00 | |||
FANCG Antibody (F-8) Alexa Fluor® 790 | sc-393382 AF790 | 200 µg/ml | $364.00 |