FAF1 Antibody (E-4): sc-393965
- FAF1 Antibody (E-4) is a mouse monoclonal IgG2b κ FAF1 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 182-480 mapping within an internal region of FAF1 of human origin
- FAF1 Antibody (E-4) is recommended for detection of FAF1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-FAF1 Antibody (E-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for FAF1 Antibody (E-4) for WB applications. These reagents are now offered in bundles with FAF1 Antibody (E-4) (see ordering information below).
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FAF1 Antibody (E-4) is a mouse monoclonal IgG2b kappa light chain antibody that detects FAF1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FAF1 (E-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FAF1, known as FAS-associated protein factor-1, plays a crucial role in the apoptotic signaling pathway, particularly in FAS ligand and tumor necrosis factor interactions. FAF1 binds to the cytoplasmic tail of the wild-type FAS receptor, enhancing the efficiency of FAS-mediated apoptosis, which is vital for maintaining cellular homeostasis and eliminating damaged or unwanted cells. Unlike other interacting proteins such as TRADD and FADD, FAF1 does not possess a death domain homologous region and cannot independently induce apoptosis without FAS activation. This unique characteristic underscores FAF1′s importance in the regulation of apoptosis, making FAF1 a significant target for studies related to cell death and survival mechanisms in various diseases, including cancer.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
FAF1 Antibody (E-4) References:
- The Fas death factor. | Nagata, S. and Golstein, P. 1995. Science. 267: 1449-56. PMID: 7533326
- FAP-1: a protein tyrosine phosphatase that associates with Fas. | Sato, T., et al. 1995. Science. 268: 411-5. PMID: 7536343
- FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. | Chinnaiyan, AM., et al. 1995. Cell. 81: 505-12. PMID: 7538907
- RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. | Stanger, BZ., et al. 1995. Cell. 81: 513-23. PMID: 7538908
- Contenders in FasL/TNF death signaling. | Cleveland, JL. and Ihle, JN. 1995. Cell. 81: 479-82. PMID: 7758103
- The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. | Hsu, H., et al. 1995. Cell. 81: 495-504. PMID: 7758105
- A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis. | Chu, K., et al. 1995. Proc Natl Acad Sci U S A. 92: 11894-8. PMID: 8524870
- Transducers of life and death: TNF receptor superfamily and associated proteins. | Baker, SJ. and Reddy, EP. 1996. Oncogene. 12: 1-9. PMID: 8552378
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FAF1 Antibody (E-4) | sc-393965 | 200 µg/ml | $322.00 | |||
FAF1 Antibody (E-4): m-IgG Fc BP-HRP Bundle | sc-530639 | 200 µg Ab; 10 µg BP | $361.00 | |||
FAF1 Antibody (E-4): m-IgGκ BP-HRP Bundle | sc-524155 | 200 µg Ab, 40 µg BP | $361.00 | |||
FAF1 Antibody (E-4): m-IgG2b BP-HRP Bundle | sc-550208 | 200 µg Ab; 10 µg BP | $361.00 | |||
FAF1 Antibody (E-4) AC | sc-393965 AC | 500 µg/ml, 25% agarose | $424.00 | |||
FAF1 Antibody (E-4) HRP | sc-393965 HRP | 200 µg/ml | $322.00 | |||
FAF1 Antibody (E-4) FITC | sc-393965 FITC | 200 µg/ml | $336.00 | |||
FAF1 Antibody (E-4) PE | sc-393965 PE | 200 µg/ml | $349.00 | |||
FAF1 Antibody (E-4) Alexa Fluor® 488 | sc-393965 AF488 | 200 µg/ml | $364.00 | |||
FAF1 Antibody (E-4) Alexa Fluor® 546 | sc-393965 AF546 | 200 µg/ml | $364.00 | |||
FAF1 Antibody (E-4) Alexa Fluor® 594 | sc-393965 AF594 | 200 µg/ml | $364.00 | |||
FAF1 Antibody (E-4) Alexa Fluor® 647 | sc-393965 AF647 | 200 µg/ml | $364.00 | |||
FAF1 Antibody (E-4) Alexa Fluor® 680 | sc-393965 AF680 | 200 µg/ml | $364.00 | |||
FAF1 Antibody (E-4) Alexa Fluor® 790 | sc-393965 AF790 | 200 µg/ml | $364.00 |