Factor H Antibody (OX24): sc-53067
- Factor H Antibody (OX24) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against purified complement factor H of human origin
- recommended for detection of serum complement protein Factor H (155 kDa) as well as a 43-49 kDa truncated form of Factor H of human origin by WB, IP, IF, IHC(P) and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- See Factor H (C18/3): sc-47685 for Factor H antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Factor H Antibody (OX24) for WB and IHC(P) applications. These reagents are now offered in bundles with Factor H Antibody (OX24) (see ordering information below).
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Factor H Antibody (OX24) is a mouse monoclonal IgG1 antibody that detects Factor H in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Factor H is a crucial serum glycoprotein composed of 1213 amino acids, organized into 20 short consensus repeats (SCRs) that are vital for regulating the alternative complement pathway. This regulation is essential for maintaining immune homeostasis and preventing excessive inflammation, which can lead to tissue damage. Additionally, Factor H plays a significant role outside the complement system by interacting with integrin receptor CD11b/CD18 and binding to glycosaminoglycans on cell surfaces, which is important for modulating cellular responses during immune reactions. Notably, deficiencies in Factor H are linked to acute renal diseases, highlighting Factor H′s importance in both immune function and kidney health. Anti-Factor H antibody (OX24) is an invaluable tool for researchers studying complement regulation and its implications in various diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Factor H Antibody (OX24) References:
- Complement factor H and hemolytic uremic syndrome. | Zipfel, PF., et al. 2001. Int Immunopharmacol. 1: 461-8. PMID: 11367530
- Updating the physiology, exploration and disease relevance of complement factor H. | Buhé, V., et al. 2010. Int J Immunopathol Pharmacol. 23: 397-404. PMID: 20646335
- Factor H-related protein 1 neutralizes anti-factor H autoantibodies in autoimmune hemolytic uremic syndrome. | Strobel, S., et al. 2011. Kidney Int. 80: 397-404. PMID: 21677636
- Functional anatomy of complement factor H. | Makou, E., et al. 2013. Biochemistry. 52: 3949-62. PMID: 23701234
- Reference Intervals of Factor H and Factor H-Related Proteins in Healthy Children. | van Beek, AE., et al. 2018. Front Immunol. 9: 1727. PMID: 30116238
- Factor H Autoantibodies and Membranous Nephropathy. | Seikrit, C., et al. 2018. N Engl J Med. 379: 2479-2481. PMID: 30575481
- Deregulation of Factor H by Factor H-Related Protein 1 Depends on Sialylation of Host Surfaces. | Dopler, A., et al. 2021. Front Immunol. 12: 615748. PMID: 33732239
- Homodimeric Minimal Factor H: In Vivo Tracking and Extended Dosing Studies in Factor H Deficient Mice. | Kamala, O., et al. 2021. Front Immunol. 12: 752916. PMID: 34956184
- Complement factor H inhibits endothelial cell migration through suppression of STAT3 signaling. | Li, J., et al. 2023. Exp Ther Med. 26: 408. PMID: 37522066
- Complement factor H in molecular regulation of angiogenesis. | Li, J., et al. 2024. Med Rev (2021). 4: 452-466. PMID: 39444793
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Factor H Antibody (OX24) | sc-53067 | 200 µg/ml | $316.00 | |||
Factor H Antibody (OX24): m-IgG Fc BP-HRP Bundle | sc-538971 | 200 µg Ab; 10 µg BP | $354.00 | |||
Factor H Antibody (OX24): m-IgG1 BP-HRP Bundle | sc-541186 | 200 µg Ab; 20 µg BP | $354.00 | |||
Factor H Antibody (OX24) FITC | sc-53067 FITC | 200 µg/ml | $330.00 | |||
Factor H Antibody (OX24) PE | sc-53067 PE | 200 µg/ml | $343.00 |