Factor H Antibody (OX23): sc-53066
- Factor H Antibody (OX23) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- raised against purified complement factor H of human origin
- recommended for detection of Factor H of human origin by WB, IP, IHC(P) and ELISA
- See Factor H (C18/3): sc-47685 for Factor H antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Factor H Antibody (OX23) for WB and IHC(P) applications. These reagents are now offered in bundles with Factor H Antibody (OX23) (see ordering information below).
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Factor H Antibody (OX23) is a mouse monoclonal IgG1 antibody that detects Factor H in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Factor H is a crucial serum glycoprotein composed of 1213 amino acids, organized into 20 short consensus repeats (SCRs), which are essential for diverse functions in the immune system. Factor H (OX23) antibody recognizes a protein that plays a pivotal role in regulating the alternative complement pathway, acting as a cofactor for Factor I, which inactivates C3b, thereby preventing excessive complement activation that can lead to tissue damage. Factor H also engages in various interactions outside the complement system, including binding to the integrin receptor CD11b/CD18 and associating with glycosaminoglycans on cell surfaces, which is vital for modulating immune responses and maintaining cellular homeostasis. Deficiencies in Factor H are linked to acute renal diseases, highlighting Factor H′s significance in both health and disease. Anti-Factor H antibody (OX23) serves as an invaluable tool for researchers studying the complement system and its implications in various pathological conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Factor H Antibody (OX23) References:
- Factor H family proteins and human diseases. | Józsi, M. and Zipfel, PF. 2008. Trends Immunol. 29: 380-7. PMID: 18602340
- Factor H autoantibodies in membranoproliferative glomerulonephritis. | Goodship, TH., et al. 2012. Mol Immunol. 52: 200-6. PMID: 22721707
- IgM Autoantibodies to Complement Factor H in Atypical Hemolytic Uremic Syndrome. | Cugno, M., et al. 2021. J Am Soc Nephrol. 32: 1227-1235. PMID: 33712527
- Intracellular Factor H Drives Tumor Progression Independently of the Complement Cascade. | Daugan, MV., et al. 2021. Cancer Immunol Res. 9: 909-925. PMID: 34039652
- Complement factor H variants are associated with microangiopathy lesions in IgA nephropathy. | Hou, W., et al. 2022. Int Immunopharmacol. 112: 109234. PMID: 36113314
- ADAMTS7-Mediated Complement Factor H Degradation Potentiates Complement Activation to Contributing to Renal Injuries. | Ma, Z., et al. 2023. J Am Soc Nephrol. 34: 291-308. PMID: 36735376
- Reduced binding of apoE4 to complement factor H promotes amyloid-β oligomerization and neuroinflammation. | Chernyaeva, L., et al. 2023. EMBO Rep. 24: e56467. PMID: 37155564
- Efficacy of GalNAc C3 siRNAs in factor H-deficient mice with C3 glomerulopathy. | Zanchi, C., et al. 2024. Mol Immunol. 168: 10-16. PMID: 38368725
- Gliosis-dependent expression of complement factor H truncated variants attenuates retinal neurodegeneration following ischemic injury. | Biber, J., et al. 2024. J Neuroinflammation. 21: 56. PMID: 38388518
- Complement factor H: a novel innate immune checkpoint in cancer immunotherapy. | Saxena, R., et al. 2024. Front Cell Dev Biol. 12: 1302490. PMID: 38389705
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Factor H Antibody (OX23) | sc-53066 | 200 µg/ml | $316.00 | |||
Factor H Antibody (OX23): m-IgGκ BP-HRP Bundle | sc-534054 | 200 µg Ab; 40 µg BP | $354.00 | |||
Factor H Antibody (OX23): m-IgG1 BP-HRP Bundle | sc-538855 | 200 µg Ab; 20 µg BP | $354.00 |