Factor H Antibody (1H10): sc-81575

Factor H Antibody (1H10) is a mouse monoclonal IgG1 antibody that detects Factor H in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Factor H is a crucial serum glycoprotein composed of 1213 amino acids, organized into 20 short consensus repeats (SCRs), which are essential for its diverse functions in the immune system. Factor H (1H10) antibody recognizes a protein that plays a pivotal role in regulating the alternative complement pathway, acting as a cofactor for Factor I, which inactivates C3b, thereby preventing excessive complement activation that can lead to tissue damage. Beyond its role in the complement system, Factor H is also involved in various interactions with cellular components, including binding to the integrin receptor CD11b/CD18 and associating with glycosaminoglycans on cell surfaces, which is vital for modulating immune responses and maintaining homeostasis. Notably, deficiencies in Factor H are linked to acute renal diseases, highlighting its importance in kidney health and disease. Anti-Factor H antibody (1H10) is an invaluable tool for researchers studying the complement system and its implications in various pathological conditions.

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Factor H Antibody (1H10) References:

1. Molecular Interactions between Complement Factor H and Its Heparin and Heparan Sulfate Ligands.  |  Perkins, SJ., et al. 2014. Front Immunol. 5: 126. PMID: 24744754
2. Plasma Complement factor H in Alzheimer's Disease.  |  Williams, MA., et al. 2015. J Alzheimers Dis. 45: 369-72. PMID: 25589717
3. Moss-Produced, Glycosylation-Optimized Human Factor H for Therapeutic Application in Complement Disorders.  |  Michelfelder, S., et al. 2017. J Am Soc Nephrol. 28: 1462-1474. PMID: 27932477
4. Broad vaccine protection against Neisseria meningitidis using factor H binding protein.  |  Findlow, J., et al. 2020. Vaccine. 38: 7716-7727. PMID: 32878710
5. Quantification of Factor H Mediated Self vs. Non-self Discrimination by Mathematical Modeling.  |  Tille, A., et al. 2020. Front Immunol. 11: 1911. PMID: 33013842
6. Contribution of functional and quantitative genetic variants of Complement Factor H and Factor H-Related (FHR) proteins on renal pathology.  |  Gómez Delgado, I. and Sánchez-Corral, P. 2021. Nefrologia (Engl Ed).. PMID: 34412931
7. Contribution of functional and quantitative genetic variants of Complement Factor H and Factor H-Related (FHR) proteins on renal pathology.  |  Gómez Delgado, I. and Sánchez-Corral, P. 2022. Nefrologia (Engl Ed). 42: 280-289. PMID: 36154806
8. Evaluating the clinical utility of measuring levels of factor H and the related proteins.  |  Banerjee, P., et al. 2022. Mol Immunol. 151: 166-182. PMID: 36162225
9. Rare germline complement factor H variants in patients with paroxysmal nocturnal hemoglobinuria.  |  Prata, PH., et al. 2023. Blood. 141: 1812-1816. PMID: 36626252
10. IgM autoantibodies to complement factor H in C3 glomerulopathy.  |  Cugno, M., et al. 2024. J Nephrol. 37: 1415-1416. PMID: 38824229

The preferred Factor H antibody is Factor H Antibody (C18/3): sc-47685.