Exo70 Antibody (H-9): sc-514257

Exo70 Antibody (H-9) is a mouse monoclonal IgG2a antibody that detects Exo70 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Exo70, also known as EXOC7, is a 735 amino acid peripheral membrane protein that plays a pivotal role in the exocyst complex, a multi-protein assembly essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. This complex is crucial for various cellular processes, including hormone and neurotransmitter secretion, cell growth, and maintaining cell polarity. Exo70′s localization to both the cytoplasm and cell membrane facilitates the docking of exocytic vesicles, ensuring efficient membrane trafficking and communication between cells. Notably, Exo70 participates in insulin-induced protein docking, highlighting its importance in metabolic regulation. Alternative splicing of the Exo70 gene results in the expression of four distinct isoforms, which may have specialized functions in different cellular contexts. With its ability to interact with other components of the exocyst complex, anti-Exo70 antibody (H-9) serves as an invaluable tool for researchers studying membrane dynamics and exocytosis.

The preferred Exo70 antibody is Exo70 Antibody (D-6): sc-365825.