Exo70 Antibody (D-6): sc-365825

Exo70 Antibody (D-6) is a mouse monoclonal IgG2b kappa light chain antibody that detects Exo70 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-Exo70 antibody (D-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Exo70, also known as EXOC7, is a critical component of the exocyst complex, which is essential for the proper targeting of exocytic vesicles to specific docking sites on the plasma membrane. This complex plays a vital role in exocytosis, a process crucial for membrane trafficking, hormone and neurotransmitter secretion, and the incorporation of membrane proteins and lipids into the plasma membrane. Exo70′s localization to both the cytoplasm and cell membrane facilitates vesicle docking, particularly in response to insulin signaling, thereby influencing cell-cell communication, growth, and polarity. Exo70 consists of 735 amino acids and undergoes alternative splicing, resulting in four distinct isoforms, which may have unique regulatory roles in cellular processes.

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Exo70 Antibody (D-6) References:

1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.  |  Kikuno, R., et al. 1999. DNA Res. 6: 197-205. PMID: 10470851
2. The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene.  |  Brymora, A., et al. 2001. J Biol Chem. 276: 29792-7. PMID: 11406615
3. The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin.  |  Inoue, M., et al. 2003. Nature. 422: 629-33. PMID: 12687004
4. NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex.  |  Sans, N., et al. 2003. Nat Cell Biol. 5: 520-30. PMID: 12738960
5. Ral GTPases regulate exocyst assembly through dual subunit interactions.  |  Moskalenko, S., et al. 2003. J Biol Chem. 278: 51743-8. PMID: 14525976
6. The mammalian exocyst, a complex required for exocytosis, inhibits tubulin polymerization.  |  Wang, S., et al. 2004. J Biol Chem. 279: 35958-66. PMID: 15205466
7. Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70.  |  Xu, KF., et al. 2005. Proc Natl Acad Sci U S A. 102: 2784-9. PMID: 15705715
8. Exo70 interacts with the Arp2/3 complex and regulates cell migration.  |  Zuo, X., et al. 2006. Nat Cell Biol. 8: 1383-8. PMID: 17086175
9. Subunit structure of the mammalian exocyst complex.  |  Kee, Y., et al. 1997. Proc Natl Acad Sci U S A. 94: 14438-43. PMID: 9405631

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Exo70 Antibody (D-6) has 12 citations in a variety of scientific publications.

Primary antibodies like Anti-Exo70 Antibody (D-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Exo70 Antibody (D-6) Specifications

Alternate Product Name: Exo70

Product Clone Name: D-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 436-735

Epitope Target: Exo70

Epitope Species: human

Product Reactivity/Detection: Exo70

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 12 citations in various scientific publications

Available Conjugates/Forms for Exo70 Antibody (D-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin