ERp57 Antibody (4E69): sc-71075
- ERp57 Antibody (4E69) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- raised against recombinant human ERp57
- recommended for detection of ERp57 of mouse, rat and human origin by WB, IP and IF; also reactive with additional species, including canine
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for ERp57 Antibody (4E69) for WB applications. This reagent is now offered in a bundle with ERp57 Antibody (4E69) (see ordering information below).
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ERp57 Antibody (4E69) is a mouse monoclonal IgG1 antibody that detects ERp57 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). ERp57, also known as GRP57, GRP58, ERp60, and ERp61, plays a crucial role in the major histocompatibility complex (MHC) class I pathway, which is essential for the immune response against intracellular pathogens. ERp57 is primarily located in the endoplasmic reticulum, where ERp57 interacts with MHC class I molecules and chaperones, facilitating proper folding and assembly of these molecules before presenting antigens to cytotoxic T lymphocytes. ERp57′s localization in the endoplasmic reticulum ensures MHC class I molecules are correctly processed and presented on the cell surface, enabling the immune system to recognize and eliminate infected cells. The human ERp57 gene, located on chromosome 15q15, encodes a 505 amino acid protein containing two conserved Trp-Cys-Gly-His-Cys-Lys motifs, highlighting evolutionary importance. ERp57 may exhibit multifunctional properties, acting as a protease, protein disulfide isomerase, or phospholipase, which further underscores significance in maintaining cellular homeostasis and immune function. Anti-ERp57 antibody (4E69) is an invaluable tool for researchers studying the intricacies of immune responses and molecular mechanisms underlying antigen presentation.
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ERp57 Antibody (4E69) References:
- ERp57 modulates STAT3 signaling from the lumen of the endoplasmic reticulum. | Coe, H., et al. 2010. J Biol Chem. 285: 6725-38. PMID: 20022947
- ERp57 modulates mitochondrial calcium uptake through the MCU. | He, J., et al. 2014. FEBS Lett. 588: 2087-94. PMID: 24815697
- The disulfide isomerase ERp57 is required for fibrin deposition in vivo. | Zhou, J., et al. 2014. J Thromb Haemost. 12: 1890-7. PMID: 25156521
- Functional Role of the Disulfide Isomerase ERp57 in Axonal Regeneration. | Castillo, V., et al. 2015. PLoS One. 10: e0136620. PMID: 26361352
- Increased ERp57 Expression in HBV-Related Hepatocellular Carcinoma: Possible Correlation and Prognosis. | Liu, M., et al. 2017. Biomed Res Int. 2017: 1252647. PMID: 28373975
- Protein disulfide isomerase ERp57 protects early muscle denervation in experimental ALS. | Rozas, P., et al. 2021. Acta Neuropathol Commun. 9: 21. PMID: 33541434
- ER Stress in ERp57 Knockout Knee Joint Chondrocytes Induces Osteoarthritic Cartilage Degradation and Osteophyte Formation. | Rellmann, Y., et al. 2021. Int J Mol Sci. 23: PMID: 35008608
- PDIA3/ERp57 promotes a matrix-rich secretome that stimulates fibroblast adhesion through CCN2. | Hellewell, AL., et al. 2022. Am J Physiol Cell Physiol. 322: C624-C644. PMID: 35196163
- Distinct role of ERp57 and ERdj5 as a disulfide isomerase and reductase during ER protein folding. | Robinson, PJ., et al. 2023. J Cell Sci. 136: PMID: 36655611
- Erp57 facilitates ZIKV-induced DNA damage via NS2B/NS3 complex formation. | Wang, Y., et al. 2024. Emerg Microbes Infect. 13: 2417864. PMID: 39404735
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ERp57 Antibody (4E69) | sc-71075 | 200 µg/ml | $322.00 | |||
ERp57 Antibody (4E69): m-IgG Fc BP-HRP Bundle | sc-539342 | 200 µg Ab; 10 µg BP | $361.00 |