ERK 5 Antibody (12F2): sc-81460
- ERK 5 Antibody (12F2) is a mouse monoclonal IgG1, cited in 3 publications, provided at 50 µg/0.5 ml
- raised against the N-terminus of ERK 5 of human origin
- recommended for detection of ERK 5 of mouse, rat, human and canine origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ERK 5 Antibody (12F2). This work is in progress.
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ERK 5 Antibody (12F2) is a mouse monoclonal IgG1 antibody that detects ERK 5 in mouse, rat, human, and canine samples through applications such as western blotting (WB) and immunoprecipitation (IP). ERK 5, a member of the mitogen-activated protein kinase (MAPK) family, plays a crucial role in various cellular processes, including cell proliferation, differentiation, and survival, making ERK 5 essential for normal cellular function and response to external stimuli. ERK 5 is primarily located in the cytoplasm and can translocate to the nucleus upon activation, where ERK 5 regulates gene expression by phosphorylating transcription factors. The ability of ERK 5 to shuttle between the cytoplasm and nucleus is vital for function, as this movement allows for the integration of extracellular signals into appropriate cellular responses. ERK 5 interacts with several key proteins, including MEF2 transcription factors, which are involved in muscle development and neuronal function, highlighting ERK 5′s importance in both developmental and physiological processes. With specific reactivity and versatile applications, anti-ERK 5 antibody (12F2) serves as an invaluable tool for researchers studying MAPK signaling pathways and their implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ERK 5 Antibody (12F2) References:
- Impact of ERK5 on the Hallmarks of Cancer. | Stecca, B. and Rovida, E. 2019. Int J Mol Sci. 20: PMID: 30901834
- Targeted Avenues for Cancer Treatment: The MEK5-ERK5 Signaling Pathway. | Pereira, DM. and Rodrigues, CMP. 2020. Trends Mol Med. 26: 394-407. PMID: 32277933
- Platelet TLR4-ERK5 Axis Facilitates NET-Mediated Capturing of Circulating Tumor Cells and Distant Metastasis after Surgical Stress. | Ren, J., et al. 2021. Cancer Res. 81: 2373-2385. PMID: 33687949
- MEK5-ERK5 Axis Promotes Self-renewal and Tumorigenicity of Glioma Stem Cells. | Fukasawa, K., et al. 2023. Cancer Res Commun. 3: 148-159. PMID: 36968222
- Modulation of ERK5 Activity as a Therapeutic Anti-Cancer Strategy. | Miller, DC., et al. 2023. J Med Chem. 66: 4491-4502. PMID: 37002872
- An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and Atherosclerosis. | Abe, JI., et al. 2023. Circ Res. 133: 25-44. PMID: 37264926
- The significance of ERK5 catalytic-independent functions in disease pathways. | Le, NT. 2023. Front Cell Dev Biol. 11: 1235217. PMID: 37601096
- MAP kinase ERK5 modulates cancer cell sensitivity to extrinsic apoptosis induced by death-receptor agonists. | Espinosa-Gil, S., et al. 2023. Cell Death Dis. 14: 715. PMID: 37919293
- An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma. | Casillo, SM., et al. 2024. Cell Rep. 43: 113557. PMID: 38113141
- Silymarin prevents endothelial dysfunction by upregulating Erk-5 in oxidized LDL exposed endothelial cells. | Patel, R., et al. 2024. Microvasc Res. 153: 104667. PMID: 38307406
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ERK 5 Antibody (12F2) | sc-81460 | 50 µg/0.5 ml | $316.00 |