ERK 5 Activators
The class of ERK5 activators comprises a diverse array of chemicals that either directly activate or indirectly modulate the extracellular signal-regulated kinase 5 (ERK5). XMD8-92 is a potent and selective ERK5 inhibitor, directly targeting ERK5 to impede its kinase activity, offering a specific tool for researchers to dissect ERK5-mediated signaling intricacies. BIX02189 and BIM-8 are selective inhibitors of MEK5, an upstream kinase that activates ERK5, leading to indirect downregulation of ERK5 activity. This highlights the essential role of MEK5 in ERK5 activation and the subsequent cellular processes governed by ERK5-mediated signaling pathways. sc-1, BH3I-1, EGCG, and Luteolin are compounds that indirectly activate ERK5 through intricate signaling networks. sc-1's impact on upstream components leads to enhanced ERK5 activity, suggesting a potential avenue for modulating ERK5-mediated cellular processes. BH3I-1 influences ERK5 indirectly through its modulation of Bcl-xL, revealing a signaling node that intersects with ERK5-mediated pathways. Natural compounds like EGCG and Luteolin showcase the versatility of fine-tuning ERK5 activity through intricate signaling networks, providing potential avenues for targeted interventions.
IPA-3 and JNK-IN-8 indirectly downregulate ERK5 activity by targeting PAK1 and JNK, respectively, demonstrating the interconnected nature of signaling networks. These inhibitors disrupt specific components of the regulatory pathway, influencing ERK5-mediated cellular processes. Molidustat indirectly activates ERK5 through the HIF-1α pathway, unveiling a connection between hypoxia signaling and ERK5 regulation. Parthenolide indirectly influences ERK5 activity by inhibiting NF-κB, revealing a potential crosstalk between inflammatory signaling and ERK5 regulation. These ERK5 activators, with their diverse mechanisms of action, provide valuable tools for researchers studying ERK5 and its role in various cellular processes. Whether through direct inhibition, modulation of upstream kinases, or influence on intricate signaling networks, these chemicals contribute to our understanding of the complex regulatory networks governing ERK5-mediated cellular functions.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
XMD 8-92 (free base) | 1234480-50-2 | sc-364068 sc-364068A sc-364068B sc-364068C | 5 mg 10 mg 100 mg 1 g | $235.00 $340.00 $1700.00 $10330.00 | 10 | |
XMD8-92 is a potent and selective ERK5 inhibitor. By directly targeting ERK5, XMD8-92 inhibits its kinase activity, impeding downstream signaling cascades. This direct inhibition highlights the critical role of ERK5 in various cellular processes, and the specificity of XMD8-92 offers a tool for researchers to dissect the intricacies of ERK5-mediated signaling and its impact on cellular functions. | ||||||
Bisindolylmaleimide VIII | 138516-31-1 | sc-24005 | 1 mg | $48.00 | 6 | |
BIM-8 is a selective inhibitor of MEK5, an upstream kinase that activates ERK5. By blocking MEK5, BIM-8 indirectly downregulates ERK5 activity. This inhibition disrupts the MEK5-ERK5 signaling cascade, highlighting the indispensable role of MEK5 in ERK5 activation and the subsequent cellular processes governed by ERK5-mediated signaling pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a polyphenol in green tea, indirectly activates ERK5 by influencing upstream signaling pathways. Its impact on kinases and growth factor receptors leads to enhanced ERK5 activity. This indirect activation highlights the potential of natural compounds, like EGCG, to modulate ERK5-mediated cellular processes through intricate signaling networks, providing insights into the complex regulation of ERK5. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
Luteolin is a flavonoid that indirectly activates ERK5 through multiple signaling pathways. By influencing kinases and growth factor receptors upstream of ERK5, luteolin enhances ERK5 activity. This indirect modulation showcases the versatility of natural compounds in fine-tuning ERK5-mediated cellular processes through intricate signaling networks, offering a potential avenue for targeted interventions. | ||||||
IPA 3 | 42521-82-4 | sc-204016 sc-204016A | 5 mg 50 mg | $94.00 $458.00 | 6 | |
IPA-3 is an inhibitor of PAK1, which is involved in the ERK5 signaling pathway. By blocking PAK1, IPA-3 indirectly downregulates ERK5 activity. This inhibition disrupts the PAK1-ERK5 signaling cascade, highlighting the interconnected nature of signaling networks and the potential for modulating ERK5-mediated cellular processes by targeting specific components of its regulatory pathway. | ||||||
BAY 85-3934 | 1154028-82-6 | sc-507384 | 5 mg | $205.00 | ||
Molidustat, an HIF-prolyl hydroxylase inhibitor, indirectly activates ERK5 through the HIF-1α pathway. By stabilizing HIF-1α, Molidustat impacts a signaling node that intersects with ERK5-mediated pathways, leading to enhanced ERK5 activity. This indirect activation suggests a potential avenue for modulating ERK5 activity through the HIF-1α pathway, unveiling a connection between hypoxia signaling and ERK5 regulation. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide is a sesquiterpene lactone that indirectly influences ERK5 activity by inhibiting NF-κB. By blocking NF-κB, parthenolide impacts a signaling node that intersects with ERK5-mediated pathways. This indirect regulation suggests a potential avenue for modulating ERK5 activity by targeting NF-κB, unveiling a connection between inflammatory signaling and ERK5 regulation. | ||||||
JNK Inhibitor XVI | 1410880-22-6 | sc-364745 | 10 mg | $357.00 | 5 | |
JNK-IN-8 is a selective inhibitor of JNK, which can indirectly modulate ERK5 activity. By blocking JNK, JNK-IN-8 influences a signaling node that intersects with ERK5-mediated pathways. This indirect regulation suggests a potential crosstalk between JNK and ERK5 signaling, providing insights into the complex regulatory networks governing ERK5-mediated cellular processes. | ||||||