ErbB4/HER4 Antibody (3F168): sc-71070

ErbB-4 Antibody (3F168) is a mouse monoclonal IgG2b antibody that detects ErbB-4 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. ErbB-4 plays a crucial role in cell signaling pathways that regulate cell proliferation and differentiation, making ErbB-4 a significant player in various physiological processes and a potential target in cancer research. ErbB-4 is primarily located in the cell membrane, where ErbB-4 functions as a receptor tyrosine kinase. Upon ligand binding, ErbB-4 can form homodimers or heterodimers with other members of the EGF receptor family, which is essential for initiating downstream signaling cascades that influence cellular responses. ErbB-4 expression is notably high in breast carcinoma cell lines, as well as in normal tissues such as skeletal muscle, heart, pituitary, brain, and cerebellum, highlighting ErbB-4′s importance in both normal physiology and disease states. Anti-ErbB-4 antibody (3F168) recognition of ErbB-4 in various applications makes anti-ErbB-4 antibody (3F168) an invaluable tool for researchers studying ErbB-4′s role in cancer and other conditions.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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ErbB4/HER4 Antibody (3F168) References:

1. Neuregulins signaling via a glial erbB-2-erbB-4 receptor complex contribute to the neuroendocrine control of mammalian sexual development.  |  Ma, YJ., et al. 1999. J Neurosci. 19: 9913-27. PMID: 10559400
2. The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses.  |  Garcia, RA., et al. 2000. Proc Natl Acad Sci U S A. 97: 3596-601. PMID: 10725395
3. Correlation between c-erbB-4 receptor expression and response to gemcitabine-cisplatin chemotherapy in non-small-cell lung cancer.  |  Merimsky, O., et al. 2001. Ann Oncol. 12: 1127-31. PMID: 11583195
4. EGFR family expression in breast carcinomas. c-erbB-2 and c-erbB-4 receptors have different effects on survival.  |  Suo, Z., et al. 2002. J Pathol. 196: 17-25. PMID: 11748637
5. Chimeric receptor analyses of the interactions of the ectodomains of ErbB-1 with epidermal growth factor and of those of ErbB-4 with neuregulin.  |  Kim, JH., et al. 2002. Eur J Biochem. 269: 2323-9. PMID: 11985614
6. Expression of ErbB-3 and ErbB-4 protooncogene proteins in oral squamous cell carcinoma: a pilot study.  |  de Vicente, JC., et al. 2003. Med Oral. 8: 374-81. PMID: 14595263
7. Changes in the expression and cytological localization of betacellulin and its receptors (ErbB-1 and ErbB-4) in the trophoblasts in human placenta over the course of pregnancy.  |  Tanimura, K., et al. 2004. Eur J Endocrinol. 151: 93-101. PMID: 15248827
8. Simultaneous expression of c-erbB-1, c-erbB-2, c-erbB-3 and c-erbB-4 receptors in non-small-cell lung carcinomas: correlation with clinical outcome.  |  Koutsopoulos, AV., et al. 2007. Lung Cancer. 57: 193-200. PMID: 17442448
9. Expression of c-erbB-3 and c-erbB-4 proteins in papillary thyroid carcinomas.  |  Haugen, DR., et al. 1996. Cancer Res. 56: 1184-8. PMID: 8640794
10. Expression of mRNA for heregulin and its receptor, ErbB-3 and ErbB-4, in human upper gastrointestinal mucosa.  |  Kataoka, H., et al. 1998. Life Sci. 63: 553-64. PMID: 9718081

The preferred ErbB4/HER4 antibody is ErbB4/HER4 Antibody (C-7): sc-8050.