ERAB Antibody (E-10): sc-393693
- ERAB Antibody (E-10) is a mouse monoclonal IgG2b κ ERAB antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 181-261 mapping at the C-terminus of ERAB of human origin
- ERAB Antibody (E-10) is recommended for detection of ERAB of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-ERAB Antibody (E-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ERAB Antibody (E-10) for WB applications. These reagents are now offered in bundles with ERAB Antibody (E-10) (see ordering information below).
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ERAB Antibody (E-10) is a mouse monoclonal IgG2b kappa light chain antibody that detects ERAB protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ERAB (E-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ERAB protein, also known as endoplasmic reticulum-associated β-Amyloid-binding protein, plays a crucial role in cellular response to β-Amyloid, a neurotoxic peptide linked to Alzheimer′s disease. ERAB protein is primarily located in the endoplasmic reticulum, where ERAB protein is involved in processing and degradation of misfolded proteins, vital for maintaining cellular homeostasis and preventing neurodegeneration. ERAB protein localization in the endoplasmic reticulum allows for immediate response to β-Amyloid accumulation, facilitating cellular mechanisms that mitigate toxic effects. ERAB protein functions as a NAD+-dependent dehydrogenase, constitutively expressed in various tissues and overexpressed in neurons affected by Alzheimer′s disease. Research has shown that cells overexpressing ERAB protein exhibit increased sensitivity to β-Amyloid-induced stress, and inhibiting ERAB protein activity can prevent cell death, underscoring ERAB protein′s critical role in Alzheimer′s disease pathophysiology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ERAB Antibody (E-10) References:
- A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease. | Hensley, K., et al. 1994. Proc Natl Acad Sci U S A. 91: 3270-4. PMID: 8159737
- An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease. | Yan, SD., et al. 1997. Nature. 389: 689-95. PMID: 9338779
- A human brain L-3-hydroxyacyl-coenzyme A dehydrogenase is identical to an amyloid beta-peptide-binding protein involved in Alzheimer's disease. | He, XY., et al. 1998. J Biol Chem. 273: 10741-6. PMID: 9553139
- ERAB contains a putative noncleavable signal peptide. | Sambamurti, K. and Lahiri, DK. 1998. Biochem Biophys Res Commun. 249: 546-9. PMID: 9712734
- Genetic neurodegenerative diseases: the human illness and transgenic models. | Price, DL., et al. 1998. Science. 282: 1079-83. PMID: 9804539
- The gene for the Alzheimer-associated beta-amyloid-binding protein (ERAB) is differentially expressed in the testicular Leydig cells of the azoospermic by w/w(v) mouse. | Hansis, C., et al. 1998. Eur J Biochem. 258: 53-60. PMID: 9851691
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ERAB Antibody (E-10) | sc-393693 | 200 µg/ml | $322.00 | |||
ERAB Antibody (E-10): m-IgG Fc BP-HRP Bundle | sc-530542 | 200 µg Ab; 10 µg BP | $361.00 | |||
ERAB Antibody (E-10): m-IgGκ BP-HRP Bundle | sc-524048 | 200 µg Ab, 40 µg BP | $361.00 | |||
ERAB Antibody (E-10): m-IgG2b BP-HRP Bundle | sc-550197 | 200 µg Ab; 10 µg BP | $361.00 | |||
ERAB Antibody (E-10) AC | sc-393693 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ERAB Antibody (E-10) HRP | sc-393693 HRP | 200 µg/ml | $322.00 | |||
ERAB Antibody (E-10) FITC | sc-393693 FITC | 200 µg/ml | $336.00 | |||
ERAB Antibody (E-10) PE | sc-393693 PE | 200 µg/ml | $349.00 | |||
ERAB Antibody (E-10) Alexa Fluor® 488 | sc-393693 AF488 | 200 µg/ml | $364.00 | |||
ERAB Antibody (E-10) Alexa Fluor® 546 | sc-393693 AF546 | 200 µg/ml | $364.00 | |||
ERAB Antibody (E-10) Alexa Fluor® 594 | sc-393693 AF594 | 200 µg/ml | $364.00 | |||
ERAB Antibody (E-10) Alexa Fluor® 647 | sc-393693 AF647 | 200 µg/ml | $364.00 | |||
ERAB Antibody (E-10) Alexa Fluor® 680 | sc-393693 AF680 | 200 µg/ml | $364.00 | |||
ERAB Antibody (E-10) Alexa Fluor® 790 | sc-393693 AF790 | 200 µg/ml | $364.00 |