Epiregulin Antibody (C-9): sc-376284
- Epiregulin Antibody (C-9) is a mouse monoclonal IgG2b κ Epiregulin antibody, cited in 6 publications, provided at 200 µg/ml
- raised against amino acids 1-162 representing full length Epiregulin of mouse origin
- Epiregulin Antibody (C-9) is recommended for detection of Epiregulin of mouse origin by WB, IP, IF, IHC(P) and ELISA
- Anti-Epiregulin Antibody (C-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Epiregulin Antibody (C-9). This work is in progress.
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SEE ALSO...
Epiregulin Antibody (C-9) is a mouse monoclonal IgG2b kappa light chain antibody that detects Epiregulin protein of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Epiregulin antibody (C-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Epiregulin (EPR, EREG) is an epidermal growth factor (EGF)-related peptide that plays a crucial role in regulating cell growth and differentiation. EPR activates the epidermal growth factor receptor (EGFR) and ErbB4, which are key players in cell signaling pathways that control proliferation and survival. EPR interaction with these receptors promotes cell growth and influences various physiological processes, including wound healing and tissue repair. EPR shows upregulation in pancreatic cancer, contributing to tumor growth and progression, making EPR a significant target for therapeutic intervention. Epiregulin monoclonal antibody (C-9) versatility in various applications allows researchers to explore EPR′s role in both normal physiology and disease states, providing valuable insights into EPR function and potential as a biomarker or therapeutic target.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Epiregulin Antibody (C-9) References:
- Epiregulin, a novel member of the epidermal growth factor family, is an autocrine growth factor in normal human keratinocytes. | Shirakata, Y., et al. 2000. J Biol Chem. 275: 5748-53. PMID: 10681561
- Epiregulin is Up-regulated in pancreatic cancer and stimulates pancreatic cancer cell growth. | Zhu, Z., et al. 2000. Biochem Biophys Res Commun. 273: 1019-24. PMID: 10891365
- Kv1.3 inhibition attenuates neuroinflammation through disruption of microglial calcium signaling. | Fomina, AF., et al. 2021. Channels (Austin). 15: 67-78. PMID: 33356832
- Review on Biological Characteristics of Kv1.3 and Its Role in Liver Diseases. | Liu, J., et al. 2021. Front Pharmacol. 12: 652508. PMID: 34093186
- The Kv1.3 K+ channel in the immune system and its 'precision pharmacology' using peptide toxins. | Varga, Z., et al. 2021. Biol Futur. 72: 75-83. PMID: 34554500
- Kv1.3 Channel Is Involved In Ox-LDL-induced Macrophage Inflammation Via ERK/NF-κB signaling pathway. | Zhang, Q., et al. 2022. Arch Biochem Biophys. 730: 109394. PMID: 36100082
- Characterization of endogenous Kv1.3 channel isoforms in T cells. | Serna, J., et al. 2023. J Cell Physiol. 238: 976-991. PMID: 36852591
- Proximity Labeling Proteomics Reveals Kv1.3 Potassium Channel Immune Interactors in Microglia. | Bowen, CA., et al. 2024. Mol Cell Proteomics. 23: 100809. PMID: 38936775
- BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway. | Prosdocimi, E., et al. 2024. Sci Adv. 10: eadn9361. PMID: 39231216
- Epiregulin. A novel epidermal growth factor with mitogenic activity for rat primary hepatocytes. | Toyoda, H., et al. 1995. J Biol Chem. 270: 7495-500. PMID: 7706296
- Activation of ErbB4 by the bifunctional epidermal growth factor family hormone epiregulin is regulated by ErbB2. | Riese, DJ., et al. 1998. J Biol Chem. 273: 11288-94. PMID: 9556621
- Epiregulin is a potent vascular smooth muscle cell-derived mitogen induced by angiotensin II, endothelin-1, and thrombin. | Taylor, DS., et al. 1999. Proc Natl Acad Sci U S A. 96: 1633-8. PMID: 9990076
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Epiregulin Antibody (C-9) | sc-376284 | 200 µg/ml | $316.00 | |||
Epiregulin Antibody (C-9) AC | sc-376284 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Epiregulin Antibody (C-9) HRP | sc-376284 HRP | 200 µg/ml | $316.00 | |||
Epiregulin Antibody (C-9) FITC | sc-376284 FITC | 200 µg/ml | $330.00 | |||
Epiregulin Antibody (C-9) PE | sc-376284 PE | 200 µg/ml | $343.00 | |||
Epiregulin Antibody (C-9) Alexa Fluor® 488 | sc-376284 AF488 | 200 µg/ml | $357.00 | |||
Epiregulin Antibody (C-9) Alexa Fluor® 546 | sc-376284 AF546 | 200 µg/ml | $357.00 | |||
Epiregulin Antibody (C-9) Alexa Fluor® 594 | sc-376284 AF594 | 200 µg/ml | $357.00 | |||
Epiregulin Antibody (C-9) Alexa Fluor® 647 | sc-376284 AF647 | 200 µg/ml | $357.00 | |||
Epiregulin Antibody (C-9) Alexa Fluor® 680 | sc-376284 AF680 | 200 µg/ml | $357.00 | |||
Epiregulin Antibody (C-9) Alexa Fluor® 790 | sc-376284 AF790 | 200 µg/ml | $357.00 |