Emt Antibody (G-11): sc-514176
- Emt Antibody (G-11) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 592-614 at the C-terminus of Emt of mouse origin
- recommended for detection of Emt of mouse and rat origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Emt Antibody (G-11) for WB applications. These reagents are now offered in bundles with Emt Antibody (G-11) (see ordering information below).
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Emt Antibody (G-11) is a mouse monoclonal IgG1 antibody that detects Emt in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Emt antibody (G-11) plays a crucial role in understanding the function of Emt, which is a member of the Tec family of non-receptor tyrosine kinases. Emt is essential for T cell activation and signaling, as Emt associates with CD28, a critical co-stimulatory receptor on T cells. Upon CD28 ligation, Emt becomes activated, leading to downstream signaling events that are vital for T cell proliferation and survival. The significance of Emt in immune responses highlights Emt′s potential as a therapeutic target in diseases characterized by T cell dysfunction, such as autoimmune disorders and cancer. With specific recognition of Emt in various applications, Emt (G-11) antibody serves as an invaluable tool for researchers investigating T cell biology and the underlying mechanisms of immune regulation.
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Emt Antibody (G-11) References:
- Extracellular matrix containing mutated fibrillin-1 (Fbn1) down regulates Col1a1, Col1a2, Col3a1, Col5a1, and Col5a2 mRNA levels in Tsk/+ and Tsk/Tsk embryonic fibroblasts. | Christner, PJ. and Ayitey, S. 2006. Amino Acids. 30: 445-51. PMID: 16583319
- Phylogeny of Tec family kinases identification of a premetazoan origin of Btk, Bmx, Itk, Tec, Txk, and the Btk regulator SH3BP5. | Ortutay, C., et al. 2008. Adv Genet. 64: 51-80. PMID: 19161832
- Itk signals promote neuroinflammation by regulating CD4+ T-cell activation and trafficking. | Kannan, AK., et al. 2015. J Neurosci. 35: 221-33. PMID: 25568116
- Lipid and Protein Co-Regulation of PI3K Effectors Akt and Itk in Lymphocytes. | Wang, X., et al. 2015. Front Immunol. 6: 117. PMID: 25821452
- Translocation-generated ITK-FER and ITK-SYK fusions induce STAT3 phosphorylation and CD69 expression. | Fathi, NN., et al. 2018. Biochem Biophys Res Commun. 504: 749-752. PMID: 30217447
- ITK deficiency presenting as autoimmune lymphoproliferative syndrome. | Wallace, JG., et al. 2021. J Allergy Clin Immunol. 147: 743-745.e1. PMID: 32628964
- TCR/ITK Signaling in Type 1 Regulatory T cells. | McGee, MC., et al. 2021. Adv Exp Med Biol. 1278: 115-124. PMID: 33523446
- Deletion of the Feeding-Induced Hepatokine TSK Ameliorates the Melanocortin Obesity Syndrome. | Wang, Q., et al. 2021. Diabetes. 70: 2081-2091. PMID: 34183373
- Dual Inhibition of IL-2-Inducible T-Cell Kinase (ITK) and Tropomyosin Receptor Kinase A (TRKA) as Potential Treatment for Atopic Dermatitis and Other Inflammatory and Autoimmune Diseases. | Abdel-Magid, AF. 2021. ACS Med Chem Lett. 12: 1889-1891. PMID: 34917248
- The hepatokine TSK maintains myofiber integrity and exercise endurance and contributes to muscle regeneration. | Wang, Q., et al. 2022. JCI Insight. 7: PMID: 35025761
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Emt Antibody (G-11) | sc-514176 | 200 µg/ml | $322.00 | |||
Emt Antibody (G-11): m-IgG Fc BP-HRP Bundle | sc-538599 | 200 µg Ab; 10 µg BP | $361.00 | |||
Emt Antibody (G-11): m-IgGκ BP-HRP Bundle | sc-536242 | 200 µg Ab; 40 µg BP | $361.00 | |||
Emt Antibody (G-11): m-IgG1 BP-HRP Bundle | sc-545788 | 200 µg Ab; 20 µg BP | $361.00 | |||
Emt (G-11) Neutralizing Peptide | sc-514176 P | 100 µg/0.5 ml | $69.00 |