ELL2 Antibody (G-5): sc-376611
- ELL2 Antibody (G-5) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 377-461 mapping within an internal region of ELL2 of human origin
- recommended for detection of ELL2 of mouse, rat and human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-376611 X, 200 µg/0.1 ml)
- m-IgGκ BP-HRP is the preferred secondary detection reagent for ELL2 Antibody (G-5) for WB applications. This reagent is now offered in a bundle with ELL2 Antibody (G-5) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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ELL2 Antibody (G-5) is a mouse monoclonal IgG1 antibody that detects ELL2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ELL2, or RNA polymerase II elongation factor ELL2, is a 640 amino acid nuclear protein that plays a crucial role in the regulation of transcription elongation by RNA polymerase II. Anti-ELL2 antibody (G-5) helps researchers study how ELL2 suppresses transient pausing of polymerase at various DNA sites, facilitating smooth transcription processes. ELL2 monoclonal antibody (G-5) enables investigation of a unique RNA polymerase II interaction domain that can negatively regulate polymerase activity during promoter-specific transcription initiation in vitro. ELL2 (G-5) antibody serves as an invaluable tool for researchers studying transcription regulation and its implications in various biological processes and diseases.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.
Download thiomersal SDS
ELL2 Antibody (G-5) References:
- Transcription elongation factor ELL2 drives Ig secretory-specific mRNA production and the unfolded protein response. | Park, KS., et al. 2014. J Immunol. 193: 4663-74. PMID: 25238757
- Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma. | Swaminathan, B., et al. 2015. Nat Commun. 6: 7213. PMID: 26007630
- Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription. | Qi, S., et al. 2017. Nat Commun. 8: 14076. PMID: 28134250
- Conditional deletion of ELL2 induces murine prostate intraepithelial neoplasia. | Pascal, LE., et al. 2017. J Endocrinol. 235: 123-136. PMID: 28870994
- ELL2 regulates DNA non-homologous end joining (NHEJ) repair in prostate cancer cells. | Zang, Y., et al. 2018. Cancer Lett. 415: 198-207. PMID: 29179998
- Regulation of ELL2 stability and polyubiquitination by EAF2 in prostate cancer cells. | Yang, T., et al. 2018. Prostate. 78: 1201-1212. PMID: 30009504
- Anti-apoptotic factor Birc3 is up-regulated by ELL2 knockdown and stimulates proliferation in LNCaP cells. | Wang, Z., et al. 2019. Am J Clin Exp Urol. 7: 223-231. PMID: 31511829
- ELL2 Influences Transcription Elongation, Splicing, Ig Secretion and Growth. | Ghobrial, A., et al. 2019. J Mucosal Immunol Res. 3: PMID: 31930204
- ELL2 Is Required for the Growth and Survival of AR-Negative Prostate Cancer Cells. | Wang, Z., et al. 2020. Cancer Manag Res. 12: 4411-4427. PMID: 32606936
- ELL2, a new member of an ELL family of RNA polymerase II elongation factors. | Shilatifard, A., et al. 1997. Proc Natl Acad Sci U S A. 94: 3639-43. PMID: 9108030
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ELL2 Antibody (G-5) | sc-376611 | 200 µg/ml | $322.00 | |||
ELL2 Antibody (G-5): m-IgGκ BP-HRP Bundle | sc-552046 | 200 µg Ab; 40 µg BP | $361.00 | |||
ELL2 Antibody (G-5) X | sc-376611 X | 200 µg/0.1 ml | $322.00 |