Elf-1 Antibody (B-9): sc-133210
- Elf-1 Antibody (B-9) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 451-619 mapping at the C-terminus of Elf-1 of human origin
- recommended for detection of Elf-1 of mouse, rat and human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-133210 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Elf-1 Antibody (B-9) for WB applications. These reagents are now offered in bundles with Elf-1 Antibody (B-9) (see ordering information below).
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Elf-1 Antibody (B-9) is a mouse monoclonal IgG1 antibody that detects Elf-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Elf-1 is a crucial member of the Ets family of transcription factors, which play significant roles in regulating gene expression, particularly during T cell activation. Elf-1 (B-9) antibody targets proteins primarily located in the nucleus, where Elf-1 binds to specific DNA sequences to modulate the transcription of target genes. This nuclear localization is vital for function, as Elf-1 interacts with other transcriptional regulators and chromatin remodeling complexes, thereby influencing immune responses and cellular differentiation. The ability of Elf-1 to bind to the pocket region of the retinoblastoma protein (Rb) further underscores its importance in cell cycle regulation and tumor suppression, as Rb is a key player in controlling cell proliferation. With diverse roles in immune function and gene regulation, anti-Elf-1 antibody (B-9) serves as an essential tool for researchers studying T cell biology and the mechanisms underlying various diseases.
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Elf-1 Antibody (B-9) References:
- Elf-1 and PU.1 induce expression of gp91(phox) via a promoter element mutated in a subset of chronic granulomatous disease patients. | Voo, KS. and Skalnik, DG. 1999. Blood. 93: 3512-20. PMID: 10233904
- Elf-1 is a transcriptional regulator of the Tie2 gene during vascular development. | Dube, A., et al. 2001. Circ Res. 88: 237-44. PMID: 11157678
- Clinical relevance of Elf-1 overexpression in endometrial carcinoma. | Takai, N., et al. 2003. Gynecol Oncol. 89: 408-13. PMID: 12798703
- The significance of Elf-1 expression in epithelial ovarian carcinoma. | Takai, N., et al. 2003. Int J Mol Med. 12: 349-54. PMID: 12883651
- Elf-1 binds to GGAA elements on the FcRgamma promoter and represses its expression. | Juang, YT., et al. 2007. J Immunol. 179: 4884-9. PMID: 17878388
- Transcriptional regulation of Elf-1: locus-wide analysis reveals four distinct promoters, a tissue-specific enhancer, control by PU.1 and the importance of Elf-1 downregulation for erythroid maturation. | Calero-Nieto, FJ., et al. 2010. Nucleic Acids Res. 38: 6363-74. PMID: 20525788
- The hematopoietic regulator, ELF-1, enhances the transcriptional response to Interferon-β of the OAS1 anti-viral gene. | Larsen, S., et al. 2015. Sci Rep. 5: 17497. PMID: 26643049
- Green Tea Polyphenol EGCG Upregulates Tollip Expression by Suppressing Elf-1 Expression. | Kumazoe, M., et al. 2017. J Immunol. 199: 3261-3269. PMID: 28954885
- ELF-1 interacts with and transactivates the IgH enhancer pi site. | Akbarali, Y., et al. 1996. J Biol Chem. 271: 26007-12. PMID: 8824239
- Elf-1 contributes to the function of the complex interleukin (IL)-2-responsive enhancer in the mouse IL-2 receptor alpha gene. | Serdobova, I., et al. 1997. J Exp Med. 185: 1211-21. PMID: 9104808
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Elf-1 Antibody (B-9) | sc-133210 | 200 µg/ml | $316.00 | |||
Elf-1 Antibody (B-9): m-IgG Fc BP-HRP Bundle | sc-537355 | 200 µg Ab; 10 µg BP | $354.00 | |||
Elf-1 Antibody (B-9): m-IgGκ BP-HRP Bundle | sc-534599 | 200 µg Ab; 40 µg BP | $354.00 | |||
Elf-1 Antibody (B-9): m-IgG1 BP-HRP Bundle | sc-545152 | 200 µg Ab; 20 µg BP | $354.00 | |||
Elf-1 Antibody (B-9) X | sc-133210 X | 200 µg/0.1 ml | $316.00 |