elastin Antibody (F-5): sc-166369

Elastin Antibody (F-5) is a mouse monoclonal IgG1 antibody that detects elastin in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-elastin antibody (F-5) is crucial for studying elastin, a protein that provides elasticity and resilience to connective tissues, particularly in the extracellular matrix of arteries, where elastin plays a vital role in maintaining arterial structure and function. The unique structure of elastin, characterized by its high content of glycine, proline, and hydrophobic residues, allows elastin to form a rubber-like network through lysine-derived crosslinks, such as desmosines. This structural integrity is essential for the proper functioning of blood vessels, as elastin enables them to withstand the mechanical stress of blood flow. With aging, the cross-linking of elastin and collagen fibers can lead to a decrease in tissue elasticity, contributing to various cardiovascular issues. Mutations or deficiencies in elastin are linked to serious conditions like supravalvular aortic stenosis and Williams-Beuren syndrome, highlighting elastin′s importance in both health and disease. The human elastin gene is located on chromosome 7q11.23, making elastin a significant target for research and therapeutic interventions. Elastin (F-5) antibody serves as an invaluable tool for studying elastin dynamics in various biological contexts, providing insights into elastin′s role in vascular health and disease.

The preferred elastin antibody is elastin Antibody (BA-4): sc-58756.